the methanol extract of ichnocarpus frutescens r.br. root (meif) was evaluated for its anti-pyretic potential on normal body temperature and yeast-induced pyrexia in albino rats. yeast suspension (10 ml/kg body wt.) increased rectal temperature 19 h after subcutaneous injection. the meif, at doses of 100, 200, and 300 mg/kg body wt., p.o., produced significant reduction in normal body temperatu...

Body temperature in mammals is homeostatically regulated around a set point, which renders it independent of large variations in environmental temperature. Hypothalamic regions, including the preoptic area, act as thermoregulatory centers that receive temperature inputs from the core body through hypothalamic receptors and from the environment through skin receptors. Thermogenic and heatdissipa...

The velocity of enzyme catalysed reactions increases with temperature to a maximum beyond which enzyme activity decreases because of protein denaturation. Many biological reactions have a 10 °C temperature coefficient (Qi0) of 2; that is, their rate of reaction doubles for a 10 °C temperature increase [62]. In mammals, protein denaturation begins at about 42 °C and internal temperatures at or a...

This is the second of a two-part review on body temperature variability. Part 1 discussed historical and modern findings on average body temperatures. It also discussed endogenous sources of temperature variability, including variations caused by site of measurement; circadian, menstrual, and annual biological rhythms; fitness; and aging. Part 2 reviews the effects of exogenous masking agents -...