Many real-life applications lead to the definition of robust optimization problems where the objective function is a black box. This may be due, for example, to the fact that the objective function is evaluated through computer simulations, and that some parameters are uncertain. When this is the case, existing algorithms for optimization are not able to provide good-quality solutions in genera...

The coupling of finite element simulations to mathematical optimization techniques has contributed significantly to product improvements and cost reductions in the metal forming industries. The next challenge is to bridge the gap between deterministic optimization techniques and the industrial need for robustness. This paper introduces a generally applicable strategy for modeling and efficientl...

in this paper, we introduce a model  to optimization of milk run system that is one of vrp problem with time window and uncertainty in inventory. this approach led to the routes with minimum cost of transportation while satisfying all inventory in a given bounded set of uncertainty .the problem is formulated as a robust optimization problem. since the resulted problem illustrates that grows up ...

Natural disasters, such as earthquakes, affect thousands of people and can cause enormous financial loss. Therefore, an efficient response immediately following a natural disaster is vital to minimize the aforementioned negative effects. This research paper presents a network design model for humanitarian logistics which will assist in location and allocation decisions for multiple disaster per...

A new active set algorithm (ASA) for large-scale box constrained optimization is introduced. The algorithm consists of a nonmonotone gradient projection step, an unconstrained optimization step, and a set of rules for switching between the two steps. Numerical experiments and comparisons are presented using box constrained problems in the CUTEr and MINPACK test problem libraries. keywords: Nonm...

magnetic nanoparticles can bind to different drug delivery systems and can be used for drug targeting to a specific organ by using an external magnetic field as well as used in hyperthermia by heating in alternating magnetic fields. the characteristics of iron oxide nanoparticles are significantly affected by particle size, shape and zeta potential, among which the particle size plays the most ...

I n this research, we apply robust optimization (RO) to the problem of locating facilities in a network facing uncertain demand over multiple periods. We consider a multi-period fixed-charge network location problem for which we find (1) the number of facilities, their location and capacities, (2) the production in each period, and (3) allocation of demand to facilities. Using the RO approach w...