Objective(s) Four novel losartan analogues 5a-d were synthesized by connecting a dihydropyridine nucleus to imidazole ring. The effects of 5a and 5b on angiotensin receptors (AT') and L-type calcium channels were investigated on isolated rat aorta. Materials and Methods Aortic rings were pre-contracted with 1 pM Angiotensin II or 80 mM KCl and relaxant effects of losartan, nifedipine, 5a and...

Objective(s) Calcium-channel blockers have an important role in the treatment of several cardiovascular disorders. Derivatives of 1, 4-dihydropyridine are one of the most potent calcium antagonists. In this study four novel ', 4-dihydropyridine calcium channel blockers were synthesized and their hypotensive properties were investigated in male rats. Materials and Methods Four 1, 4-dihydropyr...

dihydropyridine calcium channel blockers consist one of the widely-used groups of drugs for the management of hypertension. in this study, antihypertensive effects of 5 newly synthesized derivatives of dhp was examined the in rat model of two-kidney, one-clip renal hypertension. the results showed that those compounds containing two nitroxy groups had less decreasing effect on map (men arterial...

new analogues of nifedipine, as a known calcium channel blocker, were synthesized by replacing the orthonitrophenyl group on position 4 with 1-(4-nitrobenzyl)-5-imidazolyl or 2-methylthio-1-(4-nitrobenzyl)-5-imidazolyl substituent. effects of the new synthesized compounds on blood pressure were studied at 15, 30 and 60 min after administration by indirect tail-cuff method and compared with nife...

In order to investigate the effect of humic acid (HA) and nano-calcium chelate on the cut flowers of gerbera cv. Dune, an experiment was performed as a completely randomized design with two factors and three replications in hydroponic conditions. The first factor included humic acid at 4 concentrations of 0 (control), 500, 1000, and 2000 mg L-1 as drench and the second factor was ass...

The calcium-dependent release of putative neurotransmitters has been studied in the chick brain. Several radioactive compounds were taken up into chick optic lobe homogenates by a highaffinity sodium-dependent transport mechanism. At a· concentration of potassium sufficient to cause extensive depolarization, a large proportion of the efflux of the accumulated labeled compounds was calcium depen...

Calcium carbonate is a cheap and readily available filler used in rubber industry. This material is not compatible with rubber matrix, so many researchers have tried to modify its surface with various materials in order to increase its hydrophobicity and improve compatibility with the rubber matrix. In this effort, surface modification of calcium carbonate was carried out by 1.5%, 3% and 4% ste...