Abstract Background Leptin exerts both protective and deleterious effects on the heart; first occurs under hypoxia- or ischemia-associated damage, second is a pro-hypertrophic factor cardiomyocytes. Therefore, leptin could represent link between obesity cardiovascular diseases. The study aimed to investigate effect of leptin—the same concentration that frequently measured in induces cardiac hyp...

In the current study, effects of acute short term administration of fructose on cardiac arrhythmias and myocardial infarction size following ischemia/reperfusion were investigated in isolated rat heart. The hearts were subjected to 30 min zero flow global ischemia followed by 120 min reperfusion. In the control group, the hearts were perfused by normal drug free Krebs-Henseleit (K/H) solution t...

conclusions gallic acid and csa combination improved antioxidant capacity and cell membrane integrity more than each one alone. therefore, it can be a therapeutic approach to reduce the i/r injury. background myocardial infarction is one of the important causes of death during old ages. gallic acid as an antioxidant or cyclosporine a (csa) as inhibitor of mitochondrial permeability transition p...

background myocardial injury caused by ischemia-reperfusion leads to cardiac dysfunction, tissue injury and metabolic changes. the production of reactive oxygen species (ros) and lipid peroxidation are accompanied by ischemia-reperfusion injury. objectives the aim of this study was to assess the cardio protective potential effects of crocin in comparison with vitamin e on antioxidant capacity i...

Objective(s) In this study, effects of chronic administration of oral natural honey against ischemia/reperfusion (I/R)-  induced cardiac arrhythmias were investigated in isolated rat heart. Materials and Methods Male Wistar rats were divided into four groups (n= 10-14 rats in each group) and fed with natural honey (1%, 2% and 4% dissolved in the drinking water) for 45 days except for the con...

In the current study, effects of acute short term administration of fructose on cardiac arrhythmias and myocardial infarction size following ischemia/reperfusion were investigated in isolated rat heart. The hearts were subjected to 30 min zero flow global ischemia followed by 120 min reperfusion. In the control group, the hearts were perfused by normal drug free Krebs-Henseleit (K/H) solution t...

Objective(s) This study aimed to examine whether acetyl-L-carnitine (ALC) was able to reduce cardiac arrhythmias and infarct size in the ischemic-reperfused isolated rat heart. Materials and Methods The isolated hearts were mounted on a Langendorff apparatus then perfused by a modified Krebs-Henseleit solution during 30 min regional ischemia and 120 min reperfusion (control) or by enriched K...

Myocardial ischemia activates cardiac spinal afferents that mediate chest pain and excitatory reflex cardiovascular responses. Platelets are activated during myocardial ischemia and release 5-hydroxytryptamine, which stimulates abdominal spinal afferents. This study investigated the role of activated platelets in excitation of cardiac spinal afferents during ischemia. Platelet-rich plasma (PRP)...