Introduction: D-galactose (D-gal) is well known as an appropriate agent to induced aging effects in the in vivo and in vitro models. In the present study, we selected crocin, the main constituent of Crocus sativus L. (Saffron), against D-gal cytotoxicity in human neuroblastoma SH-SY5Y cells. Materials and Methods:  Cells were pretreated with crocin (25-500 µM) for 24 h and then expos...

Aging is defined as the functional decline of tissues and organisms, leading to many human conditions, such cancer, neurodegenerative diseases, hair loss. Although stem cell exhaustion widely recognized a hallmark aging, our understanding state changes–specifically, dynamics transcriptome open chromatin landscape, their relationship with aging–remains incomplete. Here we present longitudinal, s...

the immune system of mammalian organisms undergoes alterations that may account for an increased susceptibility to certain infections, autoimmune diseases, or malignancies. well characterized are age related defect in t cell functions and cell mediated immunity. although it is well established that the functional properties of t cells decrease with age, its biochemical and molecular nature is p...

Abstract Humoral immune responses to vaccination are a critical component of protection from infectious diseases. Older humans simultaneously have reduced antibody production in response and an increased burden mortality when infected with viral respiratory infections such as influenza or SARS-CoV-2. Therefore, it is understand molecular drivers immunosenescence order develop strategies that be...

aging coefficient (ac) or aged-child ratio or age composition; takes into account the numbers and areas at both ends of the age distribution simultaneously. ac is the total number of individuals aged 65 years and more, divided by the total number of individuals aged 14 years, multiplied by 100. herein, age composition in iranian popu1ations, according to different provinces, place of residence ...