A direct polarographic method for the determination of chlorpheniramine maleate in pharmaceutical preparations had been developed. The method was based on the reduction of chlorpheniramine maleate in an acidic medium (pH 1.2-4.0). The effect of pH on the polarographic wave was investigated by recording d.c. polarograms in various supporting electrolytes. The calibration graphs were rectilinear ...

Objectives: This study was undertaken to compare the efficacy and safety of fexofenadine with chlorpheniramine and betamethasone in allergic rhinitis. Methods: This was a prospective observational study on 75 patients of allergic rhinitis. They were randomly divided into 3 groups of 25 patients each for receiving fexofenadine, chlorpheniramine and betamethasone respectively. Improvement of symp...

BACKGROUND Chlorpheniramine is known to cause drowsiness, and this side effect has a potential to impair performance and could be a factor in accidents. METHODS Therefore, to establish the prevalence of this drug in pilot fatalities of aviation accidents, a postmortem toxicology database--maintained at the Civil Aeromedical Institute--was examined for the presence of chlorpheniramine in the f...

we have measured the competitive antagonistic effect of chlorpheniramine in bronchi of 8 normal and 12 asthmatic subjects. classical pharmacological theory states that the degree of competitive antagonism depends only upon 1) antagonist concentration at the receptor, and 2) receptor affinity. delivery and affinity also influence agonist responsiveness, but measurement of bronchial antagonism al...

BACKGROUND Single-patient randomized clinical trials (RCTs) can be utilized to maintain methodologic precision in the analysis of treatment effect in individual patients. We describe the results of a single-patient RCT in a patient with atopic dermatitis and review practical considerations regarding the use of antihistamines. METHODS Using double-blind, crossover techniques, the patient was r...

OBJECTIVE Crocin, as an active constituent of saffron, has many biological functions including antioxidant and anti-inflammatory activities. The present study was aimed to investigate the effects of crocin and chlorpheniramine on local edema induced by histamine. MATERIALS AND METHODS Local edema was induced by subcutaneous injection of histamine (100 μl, 0.1%) in ventral surface of right hin...

Drug-induced torsades de pointes (TdP) is a rare but potentially fatal adverse effect of commonly prescribed medications including cardiac and noncardiac drugs. Importantly, many drugs have been reported to cause the characteristic Brugada syndrome-linked electrocardiography (ECG) abnormalities and/or (fatal) ventricular tachyarrhythmias. Chlorpheniramine and propranolol have the arrhythmogenic...

We have measured the competitive antagonistic effect of chlorpheniramine in bronchi of 8 normal and 12 asthmatic subjects. Classical pharmacological theory states that the degree of competitive antagonism depends only upon 1) antagonist concentration at the receptor, and 2) receptor affinity. Delivery and affinity also influence agonist responsiveness, but measurement of bronchial antagoni...

A procedure was developed and validated for measuring chlorpheniramine maleate and tincture ipecac (as emetine hydrochloride) by reversed-phase liquid chromatography with methanol-10 mM sodium heptanesulfonate (20 + 30) as the mobile phase; the pH was adjusted to 4 with acetic acid, and the flow rate was at 1.5 mL/min, with ultraviolet detection at 254 nm. Propyl paraben was used as the interna...

A double-blind clinical trial in 60 patients with perennial rhinitis was conducted to compare the efficacy and side effects of two antihistamines, terfenadine and chlorpheniramine maleate, and placebo. There was no statistically significant difference in response between active treatments and placebo. Although side effects were more frequent with chlorpheniramine this also was not statistically...