نتایج جستجو برای: chlorpheniramine

تعداد نتایج: 672  

2011
Min-Hye Kim Sang-Min Lee So-Hee Lee Hyouk-Soo Kwon Sae-Hoon Kim Sang-Heon Cho Kyung-Up Min You-Young Kim Yoon-Seok Chang

Antihistamines are commonly used to treat allergic disease, such as allergic rhinitis, urticaria, and angioedema. Although several previous reports describe hypersensitivity to antihistamines such as cetirizine and hydroxyzine, documented cases of chlorpheniramine hypersensitivity are extremely rare. Here, we report the case of a 45-year-old Korean woman who presented with urticaria after inges...

2015
Hyun-Seung Lee Woo-Jung Song Ji-Won Lee Young-Yoon Cho Han-Ki Park Min-Gyu Kang Sang-Heon Cho Seong-Wook Sohn

Chlorpheniramine is a widely prescribed H1-antihistamine for relieving urticaria or histamine-mediated allergic reactions. However, although rare, it may cause immediate hypersensitivity reactions. The diagnosis is usually made by provocation test, but its application is often limited due to comorbidities or potential risk of severe reactions. In those cases, skin tests and basophil activation ...

Journal: :Parasitology international 2006
Sunan Nakornchai Phattanapong Konthiang

Chlorpheniramine, a histamine H1 receptor antagonist, was assayed for in vitro antimalarial activity against multidrug-resistant Plasmodium falciparum K1 strain and chloroquine-resistant P. falciparum T9/94 clone, by measuring the 3H-hypoxanthine incorporation. Chlorphenirame inhibited P. falciparum K1 and T9/94 growth with IC50 values of 136.0+/-40.2 microM and 102.0+/-22.6 microM respectively...

2017
Yung-Lung Chang Chun-Shu Lin Hsing-Won Wang Kai Ren Jian Shao-Cheng Liu

Background: Aquaporin 5 (AQP5) is most likely the primary water channel in the human nasal mucosa and acts as a key tight junction protein. The signaling cascades responsible for AQP5 regulation are still works in progress. Objective: This study sought to determine the effects of histamine and chlorpheniramine on AQP5 expression in human nasal epithelial cells (HNEpC) and to detect the signalin...

Journal: :The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2009
Hee-Kyung Hong Su-Hyun Jo

Chlorpheniramine is a potent first-generation histamine H(1) receptor antagonist that can increase action potential duration and induce QT prolongation in several animal models. Since block of cardiac human ether-a-go-go-related gene (hERG) channels is one of leading causes of acquired long QT syndrome, we investigated the acute effects of chlorpheniramine on hERG channels to determine the elec...

Journal: :Antimicrobial agents and chemotherapy 1982
V M Millet M Dreisbach Y J Bryson

A total of 52 healthy, adult volunteers were randomly assigned to five treatment groups to be treated twice daily for 4 days with 100 mg of amantadine, 100 mg of rimantadine, 4 mg of chlorpheniramine or placebo alone, or 100 mg of amantadine in combination with chlorpheniramine. The results of tests measuring performance on tasks of attention, reasoning, and memory were unaffected by treatment....

2012

Objective: The need for the rational development of newer and adjuvant drugs to treat epilepsy has prompted this study of the potential anticonvulsant effect of chlorpheniramine maleate. Method The acute effect was studied in mice in single doses of 1 mg/kg, 2 mg/kg and 4 mg/kg of chlorpheniramine maleate and the chronic effect was studied in doses of 1 mg/kg and 4 mg/kg (administered daily for...

Journal: :Journal of clinical psychopharmacology 2001
J M Serra-Grabulosa C Grau C Escera M Sanchez-Turet

Although previous studies have shown that the human attention system is partially affected by chlorpheniramine, the effects of chlorpheniramine on human auditory selective attention have not yet been explored. This study examines the effects of a single dose of 4 mg of dextro-chlorpheniramine on human auditory selective attention by means of the evaluation of the event-related brain potential (...

Journal: :Pharmacological reports : PR 2008
Esmaeal Tamaddonfard Hamid Soraya Nasrin Hamzeh-Gooshchi

In this study, the effects of intraperitoneal (ip) injection of physostigmine, subcutaneous (sc) injection of atropine, and intracerebroventricular (icv) injections of histamine, chlorpheniramine (H(1)-receptor antagonist), and ranitidine (H(2)-receptor antagonist) in separate and combined treatments were investigated during yawning in rats. Physostigmine at a dose of 0.25 mg/kg produced the hi...

Journal: :Mediators of Inflammation 1994
I. Gorenne C. Labat X. Norel H. Sosse Alaoui J.-P. Gascard C. Brink

Heman airway preparations at resting tone were relaxed with either the leukotriene synthesis inhibitor BAY x1005 (3 muM), chlorpheniramine (1 muM) or the thromboxane receptor antagonist BAY u3405 (0.1 muM). The response to anti-IgE (1:1000) was 58 +/- 8% of acetylcholine pre-contraction (2.19 +/- 0.28 g). Indomethacin (3 muM) enhanced the anti-IgE-induced contraction by 28%. The anti-IgE maxima...

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