One of the important Multi-component reaction (MCRs) is the synthesis of dihydropyrano chromene derivatives by one-pot reaction. In this research, an inexpensive and effective one pot three component procedure with good yields for the synthesis of dihydro pyrano chromenes is reported. In this method, the synthesis of pyrano chromene derivatives was followed by using 4-hydroxycoumarin, malononit...

an efficient and green method for the synthesis of pyrano[3,2-c]chromene or pyrano[4,3-b]pyrone derivatives is described by using a three-component condensation process of malononitrile, aldehyde, and 4-hydroxycoumarine or 4-hydroxypyrone in [bmim]bf4-licl as an ionic liquid.

1-Methyl-1H-imidazol-3-ium 2,3,4,5,6-pentafluorophenolate [mim]C6F5O as a novel nano ionic liquid was designed, synthesized and characterized by using various techniques such as Fourier transform spectroscopy infrared (FT-IR), nuclear magnetic resonance (NMR), x-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), ener...

In(OTf)3 catalyzed microwave-assisted alkenylation of methoxyphenols was investigated. Exclusive formation of either indenes or chromenes was observed depending on the position of the methoxy group on phenol. The structures of 1H-inden-4-ol derivatives (4a-e) and 4H-chromene derivatives (5a-j) were established by NMR ((1)H & (13)C) and high-resolution mass spectra, which were further supported ...

BACKGROUND AND AIMS In the context of the increasing phenomenon of microbial resistance to usual drugs, the development of new treatment strategies and new therapeutic protocols is a constant need. Thiazolidinedione and chromone represent two important scaffolds in medicinal chemistry due to their large pharmacological applicability. METHODS We synthesized a new 5-(chromene-3-yl)methylene-2,4...

silica-bonded n-propyltriethylene-tetramine (sbnptt) was found as an efficient solid base for the synthesis of 2-amino-5-oxo-5,6,7,8-tetrahydro-4h-chromenes. chromene derivatives were obtained via the three-component condensation reaction of aromatic aldehydes, malononitrile, and dimedone at 80 oc under solvent-free conditions. the heterogeneous solid base showed much the same efficiency when u...

nano tin dioxide was employed as a catalyst for efficient and facile preparation of pyran derivatives via the one-pot three component condensation reaction of various aldehydes with malononitrile and dimedone. chromene derivatives via the one-pot three component condensation reaction of various aldehyde with malononitrile and 4-hydroxycoumarin were also synthesized by this novel catalyst. the d...

A rapid, clean, and highly efficient method for synthesis of dihydropyrano[3,2-c]chromene derivatives by one-pot, three-component condensation of aromatic aldehydes, malononitrile, and 4-hydroxycoumarin using DABCO as catalyst in solvent-free neat conditions is described. The present method has the advantages of mild reaction conditions, short reaction times, easy isolation of products, and exc...

α-Enone 1, reacts with hydrazines, hydroxylamine hydrochloride, thiourea, diethylmalonate, malononitrile ethyl cyanoacetate to give the corresponding indazole, oxime, isoxazole, quinazoline, chromene and quinoline derivatives. The structures of all the synthesized compounds were confirmed by micro analytical and spectral data. The antimicrobial and the antitumor activities of some of the synthe...