the human leukocyte antigen g (hla-g) molecule exhibits limited tissue distribution, low polymorphism and alternative splicings that generate seven hla-g isoforms. hla-g exerts multiple immunoregulatory functions. recent studies indicate an ectopic up-regulation in tumor cells that may favor their escape from anti-tumor immune responses. this study it is an effort to clarify the presence of hla...

Background:Leukemia is cancer of blood and bone marrow cells. In general, there are four types of leukemia: chronic myelogenous leukemia (CML), acute myeloid leukemia (AML), B-cell chronic lymphocytic leukemia (CLL) and acute lymphoblastic leukemia (ALL).  Fractal geometry can be introduced as one of the effective ways to detect this type of cancer. In this study, with introduc...

Chronic lymphocytic leukemia (CLL) infiltrating the skin is uncommon and can present in many different ways. The present study reports a case of CLL infiltrating multiple body areas. A 57-year-old male with a 10-year history of subclinical B-cell chronic lymphocytic leukemia (B-CLL) presented with skin hypertrophic changes of the ears, eyebrows, tip of the nose, toes and fingers. In addition, t...

Abbreviations: acute lymphoblastic leukemias, (ALLs); acute myeloid leukemia, (AML); arsenic trioxide, (ATO); B-cell chronic lymphocytic leukemia, (B-CLL); blast crisis, (BC); chronic lymphocytic leukemias, (CLL); CML-Acceleration Phase/Blast Crisis, (CML/AP/BC); CML-Bone Marrow Transplantation patients, (CML-BMT); CML-Chronic Phase patients, (CML/CP); DNA binding domain, (DBD); dominant-negati...

Chronic lymphocytic leukemia (CLL) is the most common leukemia of adults in the western world and constitutes about 33% of all leukemia's. The incidence of CLL increases with age and are more common in older population. Chronic myeloid leukemia (CML) on the contrary occurs in both young adults and elderly and is a chronic myeloproliferative disease that originates from abnormal pluripotent stem...

Light chain amyloidosis has very rarely been reported in association with chronic lymphocytic leukemia (CLL). We reported on a 76-years-old female who presented with simultaneous kappa-restricted chronic lymphocytic leukemia (CLL) and a lambda-restricted multiple myeloma with plasma cells causing AL amyloidosis involving the heart. While monoclonal immunoglobulins occasionallyproduced by CLL ha...

1. Caballero MD, Gonzalez M, Canizo MC, Orfao A, Nieto MJ, San-Miguel JF. Concomitant chronic lymphocytic leukemia (CLL) and acute myeloid leukemia. Complete remission of CLL achieved with high-dose cytosine arabinoside. Leukemia 1992; 6:856-8. 2. Conlan MG, Mosher DF. Concomitant chronic lymphocytic leukemia, acute myeloid leukemia, and thrombosis with protein C deficiency. Case report and rev...

Chronic lymphocytic leukemia (CLL) is a common adult leukemia caused by abnormal accumulation of B cells. Raval et al. (2007) now implicate dowregulation of the expression of the kinase DAPK1 both genetically and epigenetically in familial and sporadic CLL.

Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries, and mainly originates from an accumulation of abnormal B cells caused by the dysregulation of cell proliferation and apoptosis. The aberration of proliferation-related gene in CLL cells induces cell arrest at G0/G1 phase, or a small section shows rapid cell growth, which further complicates the pathogenesis of ...