Orbital or subconjunctival infiltration occurs frequently in acute and chronic lymphatic leukaemia, but only rarely in myelogenous leukaemia (Chatterjee and Sen, I 960). Chloroma, an atypical form of myeloblastic leukaemia, often manifests itself as a localized mass in the orbital periosteum, and the proptosis produced in such cases may be the first sign of the disease (Goodman and Iverson, I94...

Orbital or subconjunctival infiltration occurs frequently in acute and chronic lymphatic leukaemia, but only rarely in myelogenous leukaemia (Chatterjee and Sen, I 960). Chloroma, an atypical form of myeloblastic leukaemia, often manifests itself as a localized mass in the orbital periosteum, and the proptosis produced in such cases may be the first sign of the disease (Goodman and Iverson, I94...

Chronic myelogenous leukaemia is an uncommon disease in infancy and is usually termed congenital in cases seen at or within a few days after birth. The latter do not appear to differ from those seen later except that they are believed to have started during intra-uterine life, and Kelsey and Andersen (1939) have laid down certain criteria for the diagnosis, which might be briefly stated as symp...

Clinics and pathology Disease Myeloid malignancies: myelodysplastic syndrome (MDS) in 1/4 of cases, with various FAB diagnoses (refractory anaemia (RA), RA with ringed sideroblasts (RARS), RA with excess of blasts (RAEB), RAEB in transformation (RAEB-t), and chronic myelomonocytic leukemia (CMML)), acute non lymphocytic leukaemia (ANLL) in 60% of cases (M2-ANLL in 1/4 of all cases), blast crisi...

Patients diagnosed with inflammatory bowel disease are known to be at an increased risk of colorectal and liver cancers and of leukemia. In fact, several forms of primary and secondary hematological malignancies were rarely observed during the clinical course of inflammatory bowel diseases. The causal relationship, if any, remains undetermined. Patients needing a prolonged treatment with immu n...

Fifty-three patients with chronic myeloid leukaemia (CML) were included in this study (25 females & 28 males) and followed-up from October 2003 till October 2005 included for the evidence of acute transformation. Twenty-one patients (39.6%) transformed to acute phase , 16 patients(76.1%) of them transformed during the first 4 years of diagnosis. Fifteen patients (71.4 %) ) transformed to acute ...