Introduction: Central giant cell granuloma is a benign lesion but sometimes has aggressive proliferation composed of multinucleated giant cells in a background of spindle and ovoid mesenchymal cells. Multifocal central giant cell granuloma of jaws is very rare and usually associated with hyperparathyroidism and some syndromes. We described an un-usual case of a 22-year-old man with idi-opathic ...

PIK3CA-Related Overgrowth Spectrum (PROS) refers to rare syndromes, which are characterized by malformations and excessive tissue growth caused somatic mutations in the PIK3CA gene occurring during embryogenesis. This article discusses pathogenesis, clinical picture, diagnosis treatment of these syndromes. Some illustrations used this copied from other resources, rights authors respected not vi...

paraneoplastic syndromes result from secretion of hormones, peptides or cytokines by tumor or immune cross-reactivity between malignant and normal tissues. these conditions are rare in children, but when the clinical presentation of patients with a tumor is unusual, these syndromes should be emphasized . extrarenal tumors with renin-secretion are rare in children. they may be related to paraneo...