A 24-year-old female presented with catatonia and symptoms suggestive of Depressive Disorder. She also gave history of undocumented low grade irregular fever. The patient was worked up to rule out any organic cause or psychiatric illness. However, further investigations revealed immunological profile diagnostic of Systemic Lupus Erythematosus (SLE) with CNS involvement (CNS lupus). The diagnosi...

A 22-year-old female patient presented to the Emergency Department of a tertiary care hospital with symptoms of headache and nausea. She has been on a regular follow-up for the preceding three and a half years after being diagnosed as systemic lupus erythematosus (SLE). She had been treated earlier for SLE nephritis in the same institution, and had two relapses of nephrotic syndrome in the last...

BACKGROUND Central nervous system (CNS) involvement has been observed in 14-80% of patients with systemic lupus erythematosus (SLE). Magnetic resonance imaging (MRI) is an appropriate method for evaluating CNS involvement in these patients. Clinical manifestations and MRI findings of CNS lupus should be differentiated from other mimicking diseases such as multiple sclerosis (MS). OBJECTIVES T...

What have we learned about CNS lupus in recent years? An enormous amount of knowledge on pathophysiology of antiphospholipid antibodies, in particular, has been gathered. Although hard evidence of a direct pathogenetic role of these antibodies in cerebral lupus is still lacking, it is generally felt that the multiple microinfarctions found in the brains of lupus patients are related to their pr...

We report a case of bilateral lupus Choroidopathy and central nervous system (CNS) vasculitis in a 43-year-old female with systemic lupus erythematous. The patient improved systemically on high dose steroids and mycophenolate. Choroiditis flared and escalation of therapy with Rituximab achieved CNS disease control. Choroiditis refractory to systemic therapy improved with micropulse laser therap...

Neuropsychiatric disease may occur commonly in mixed connective tissue disorder (MCTD) and has been observed in up to 55 percent of patients. Aseptic meningitis has been described as the most common presentation, although psychosis, convulsions, peripheral neuropathy, trigeminal neuropathy, and cerebellar ataxia have also been described [1, 2]. Corticosteroid therapy is highly effective in the ...

a 22-year-old female patient presented to the emergency department of a tertiary care hospital with symptoms of headache and nausea. she has been on a regular follow-up for the preceding three and a half years after being diagnosed as systemic lupus erythematosus (sle). she had been treated earlier for sle nephritis in the same institution, and had two relapses of nephrotic syndrome in the last...

We report a 40-year-old woman with systemic lupus erythematosus (SLE) and associated inflammatory polyarthritis who presented with acute facial dystonic spasms. Her speech was also affected. An MRI brain showed bilateral symmetrical basal ganglia signal change on T2. This movement disorder was due to an acute manifestation of her lupus. Her symptoms resolved rapidly following treatment with (or...

Objective(s): Systemic lupus erythematosus (SLE) is an autoimmune disease with a wide range of clinical manifestations. Cognitive dysfunction is one of the manifestations that could present prior to the emergence of any other neuropsychiatric involvements in SLE. Cognitive dysfunction is a subtle condition occurring with ahigh frequency. However, there is no data on the correlation of cognitive...