objective: the fact that some antidepressants with strong effects on serotonin reuptake blockade fail to relieve obsessive-compulsive symptoms has caused growing interest in investigating noradrenergic function in obsessive-compulsive disorder (ocd) . in light of the above, we undertook a trial to investigate whether the combination of citalopram with nortriptyline is more effective in treating...

objective(s):multidrug resistance (mdr) of cancer cells is a major obstacle to successful chemotherapy. overexpression of breast cancer resistance protein (bcrp) is one of the major causes of mdr. in addition, it has been shown that pi3k/akt signaling pathway involves in drug resistance. therefore, we evaluated the effects of novel approaches including sirna directed against bcrp and targeted t...

hormone-independent prostate cancer cell lines are resistant to antineoplastic drugs, this study sought to determine the usefulness of lithium chloride as an inhibitor of glycogen synthase kinase-3β to increase the cytotoxic effect of doxorubicin, etoposide or vinblastine antineoplastic drugs on du145 cells. combination effect was assessed by using low and ic50 doses of drugs + lithium chloride...

the aim of this study was to evaluate the anti-nociceptive effects of a low, sub-effective dose of amitriptyline, in combination with the different doses of ethanolic and aqueous extracts of crocus sativus following sciatic nerve chronic constriction injury (cci) in rats. amitriptyline (3, 10 and 30 mg/kg, i.p.) and the extracts (25, 50 and 100 mg/kg, i.p.), were separately administered at the ...

introduction & objective: patients with major depressive are difficult to treat, and the relative efficacy of medications and cognitive therapy in the treatment of depression is still a matter of deabath. the purpose of this study was to compare the efficacies of antidepressant medication, cognitive therapy and combination of cognitive therapy and antidepressant medication. materials & methods:...

Background: Studies have reported the beneficial effects of exercise, ozone therapy, and stem cell therapy for the treatment of knee osteoarthritis.  Objectives: To reduce the duration of the treatment, we decided to investigate the synergistic effects of Endurance Training (ET), ozone therapy, and mesenchymal stem cell (MSCs) therapy separately or in combination on the cannabinoid receptors 1...

introduction various types of dermatological manifestations have been reported due to hepatitis c virus (hcv) infection and anti­hcv therapy. some of them have been described during ifn-based therapies. peg-ifn-α-2a/rbv combination is used as the international standard of treatment for hcv infection for a long time. the combination therapy yields an adverse-event profile similar to standard int...

Cancer is the second leading cause of death worldwide. Despite great efforts over many years, today cancer treatment is not very effective. The main reasons for cancer chemotherapy failure are high cytotoxicity, low response rates in solid tumors, and development of resistance. Different experimental studies have shown that drug combination using low toxicity natural compounds such as polypheno...