INTRODUCTION Most patients with Hodgkin lymphoma (HL) are cured with modern combined modality first-line treatments. Even ~ 50% of patients with relapsed/refractory HL can be cured with high-dose chemotherapy (HDCT) and autologous stem cell transplantation. However, chemotherapy and radiotherapy cause significant acute and long-term side effects and patients relapsing after HDCT have a dismal p...

In this paper, the nonlinear conjugate map is applied based on the conjugate Hasofer-Lind and Rackwitz- Fiessler (CHL-RF) method to evaluate the reliability index using the first order reliability method of the embedded nanocomposite beam, which is made of a polymer reinforced with carbon nanotubes (CNTs). The structure is simulated with the Timoshenko beam model. The Mori-Tanaka model is appli...

UNLABELLED Although Hodgkin's lymphoma (HL) was one of the first human cancers to be cured by chemotherapy, no new agents other than brentuximab vedotin (Adcetris®, CD 30 directed antibody drug conjugate) have received US Food and Drug Administration (FDA) approval for HL since 1977. Subsets of young adult patients with HL continue to relapse, even after stem cell transplantation, warranting ne...

Despite relative success of therapy for Hodgkin's lymphoma (HL), novel therapeutic agents are needed for patients with refractory or relapsed disease. Recently, anti-PD1 immunotherapy or treatment with the anti-CD30 toxin conjugate brentuximab vedotin (BV) have been associated with remissions; however, the median responses of complete responses (CRs) with the latter were only 6.7 mo. To obtain ...

Background and aims: Health literacy (HL) can affect individual health, health communication anderror in taking medicine. The aim of this study was to determine the level of HL and associated factorsamong Iranian adults.Methods: In this cross-sectional study, 240 participants over 18 years of age referring to health centersin Hamadan, west of Iran in 2015 were selected b...

The purpose of this paper is twofold. The first is to describe some simple and robust iterative schemes for nonsymmetric and indefinite elliptic boundary value problems. The schemes are based in the Sobolev space Hl (ii) and require minimal hypotheses. The second is to develop algorithms utilizing a coarse-grid approximation. This leads to iteration matrices whose eigenvalues lie in the right h...

The mechanism of doxorubicin is compared with that of doxazolidine, a doxorubicin-formaldehyde conjugate. The IC(50) for growth inhibition of 67 human cancer cell lines, but not cardiomyocytes, is 32-fold lower with doxazolidine than with doxorubicin. Growth inhibition by doxazolidine correlates better with growth inhibition by DNA cross-linking agents than with growth inhibition by doxorubicin...

Hodgkin Lymphoma HL can be cured in the large majority of younger patients, but prognosis for older patients, especially those with advanced-stage disease, has not improved substantially. The percentage of HL patients aged over 60 ranges between 15% and 35%. A minority of them is enrolled into clinical trials. HL in the elderly have some specificities: more frequent male sex, B-symptoms, advanc...