BACKGROUND Hepatitis C virus (HCV) core protein, in addition to its structural role to form the nucleocapsid assembly, plays a critical role in HCV pathogenesis by interfering in several cellular processes, including microRNA and mRNA homeostasis. The C-terminal truncated HCV core protein (C124) is intrinsically unstructured in solution and is able to interact with unspecific nucleic acids, in ...

Background: Patients need peace of mind to disclose their information to medical staff and with the lack of trust or in specific health status, they may avoid providing sensitive information for their care or might change the information. This research aims to examine the impact of perceived health status and trust propensity on privacy calculus. Methods: This research was analytical-study. 3 ...

In the Rhodobacter (Rba.) species of photosynthetic purple bacteria, a single transmembrane α-helix, PufX, is found within the core complex, an essential photosynthetic macromolecular assembly that performs the absorption and the initial processing of light energy. Despite its structural simplicity, many unresolved questions surround PufX, the most important of which is its location within the ...

By comparing 401(k) eligible and ineligible households’ wealth, this paper estimates that, on average, about one half of 401(k) balances represent new private savings, and about one quarter of 401(k) balances represent new national savings. Responses to eligibility vary considerably, however, with households who normally save the most largely contributing funds they would have saved anyway. Thi...

aim: this study aimed to assess the relationship of screen time and metabolic syndrome (mets) among iranian adolescents. materials and methods  in this nationwide study, the propensity score (ps) was used in a matched case-control study design. the data was obtained from 5,625 students aged 10-18 years, who participated in a national school-based surveillance program. mets was defined according...

1 Details on Affinity Function Computations 2 1.1 Shape Complementarity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.1.1 Skin-core Definition and Weighting . . . . . . . . . . . . . . . . . . . . . . . . 2 1.1.2 FFT based formulation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 1.2 Electrostatics (E). . . . . . . . . . . . . . . . . . . . . . . . . . ...

Characterizing the interactions between amino acid residues and lipid molecules is important for understanding the assembly of transmembrane helices and for studying membrane protein folding. In this study we develop TMLIP (TransMembrane helix-LIPid), an empirically derived propensity of individual residue types to face lipid membrane based on statistical analysis of high-resolution structures ...

Cooperative binding of ATP and RNA to DEAD-box helicases induces the closed conformation of their helicase core, with extensive interactions across the domain interface. The bound RNA is bent, and its distortion may constitute the first step towards RNA unwinding. To dissect the role of the conformational change in the helicase core for RNA unwinding, we characterized the RNA-stimulated ATPase ...