The mechanisms that regulate oxidative phosphorylation in mammalian cells are largely unknown. To address this issue, cybrids were generated by fusing osteosarcoma cells devoid of mitochondrial DNA (mtDNA) with platelets from a patient with a stop-codon mutation in cytochrome c oxidase subunit I (COX I). The molecular and biochemical characteristics of cybrids harboring varying levels of mutate...

Abstract The aim of the present study is to explore new selective anti-inflammatory compounds with low cardiovascular risk. Twelve thiadiazole derivatives incorporating different amino acid moieties were newly synthesized ( 4 – 15 ) as potential agents risks through dual COX-2/MPO inhibition. Compounds initially screened for their effect by assay COX-2, most potent 6 , 8 further tested COX-1 in...

Glomerular diseases are characterized by a sustained synthesis and accumulation of abnormal extracellular matrix proteins, such as collagen type I. The extracellular matrix transmits information to cells through interactions with membrane components, which directly activate many intracellular signaling events. Moreover, accumulating evidence suggests that eicosanoids derived from cyclooxygenase...

Cytochrome c oxidase (COX) is composed of 13 subunits, of which COX I, II, and III are encoded by a mitochondrial gene. COX I and II function as the main catalytic components, but the function of COX III is unclear. Because myocardial ischemia affects mitochondrial oxidative metabolism, we hypothesized that COX activity and expression would be affected during postischemic cardiomyopathy. This h...

the waiting time between children births are called tempo. this phenomenon plays a crucial role in the child and mother health. the purpose of the present study is determination of factors which influence this variable of interest. a significance level of 5% and power of 80% considered to calculate the required sample size for this cross sectional study. the sample size of 124 women determined ...

objective: tempo is the average waiting time to next birth for a woman. role of fertility as the most important phenomenon determining population fluctuations due to the studies of it compared with other demographic phenomena be important and review the multifarious socioeconomic factors of it share  a large effective population studies. general purpose of this study is fitting the cox model to...