Background Cryofibrinogenemia (CF) is a rare disorder characterized by the presence of an abnormal protein in plasma that precipitates when cooled and redissolves at room temperature (1). CF rarely symptomatic, therefore it often underestimated. Nevertheless, cryoprecipitation native fibrinogen could induce thrombotic occlusion small medium sized vessels; as consequence, this condition become p...

Background Cryofibrinogenemia (CF) is an under-recognized syndrome due to the lack of definitive criteria and rarity disease. CF may be essential or secondary autoimmune, neoplastic infections conditions [1] . Skin manifestations, mainly ulceration, are most common a pseudovasculitic syndrome. During COVID-19 era number cases with skin lesions get increased. Further studies needed characterize ...