Cryofibrinogenemia is a rare disorder in which plasma, not serum, forms a cryoprecipitate. Patients with cryofibrinogenemia may be asymptomatic, or they may have painful ulcers, purpura, livedo reticularis, Raynaud phenomenon, perniosis of the extremities, thrombosis, and arthralgia. Cryofibrinogenemia may be primary or secondary to an underlying disorder such as connective tissue disease, mali...

Cryofibrinogenemia is a cryopathy in which hypersensitivity to cold is a prominent feature. Cryofibrinogenemia developed in an 18-year-old Japanese female patient during methimazole therapy for Graves' disease. She developed cryopathy (livedo reticularis, Raynaud's phenomenon and acral ulcer) and polyarthralgia during methimazole therapy, and we detected cryofibrinogen in her plasma. Her sympto...

Cryofibrinogenemia is a rarely symptomatic disorder that is underrecognized due to the infrequency with which it causes symptoms. Although completely reversible, this disorder can be life threatening when untreated. In this review, the classification, pathophysiology, and clinical presentation of cryofibrinogenemia are described, based on case reports and prospective observational data. Diagnos...

Although the histologic characteristics of cryofibrinogenemia have been described in skin lesions, the literature is largely devoid of descriptions of this disorder in other organs. This series is the first to document the histopathologic manifestations of intrapulmonary, intramuscular, and renal cryofibrinogenemia. We describe the histopathologic manifestations of cryofibrinogenemia in 10 case...

Background Cryofibrinogenemia is a rare disorder that refers to the presence of cold-precipitable proteins in plasma but, unlike cryoglobulinemia, not in serum. It can manifest as vascular occlusion in cold exposed areas. It is most often secondary to various inflammatory disorders, infections or malignancy, but cases of true essential cryofibrinogenemia have been described. To the best of our ...

the most frequently studied association between a hepatitis virus and non hodgkin lymphoma (nhl) has been with hepatitis c virus (hcv). association with hepatitis b virus (hbv) is less studied. in this regard mixed cryoglobulinemia (mc) is more commonly associated with hcv than hbv. still rarer is cryofibrinogenemia in these patients.   lack of symptoms in addition its rarity delays the diagnos...