The in vivo effects of several chemotherapeutic agents on the mitotic cycle of leukemic blasts in the bone marrow were evaluated by serial measurements of cells in mitosis and in deoxyribonucleic acid (DNA) synthesis as indicated by ability to incorporate tritiated thymidine or tritiated deoxyuridine. 28 studies were done in 23 children and 1 adult. The changes in the marrow after a single inje...

High dose (1-3 g/m2 every 12 hours) cytosine arabinoside (ara-C) is a potent treatment for acute myeloid leukemia (AML) in consolidation therapy which is well known that improves the diseasefree-survival (DFS). Cerebellar neurotoxicity is well-recognized complication following high-dose cytosine arabinoside (≥3 g/m2 every 12 hours), but peripheral neurotoxicity is not common as well. This poten...

Marrow specimens obtained from 23 patients with acute myelocytic leukemia were exposed to cytosine arabinoside and/or daunorubicin in vitro, and the effects of these agents on colony formation in vitro was determined. Thymidine suicide indices were determined as well, which permitted a distinction to be made between kinetic and metabolic resistance to cytosine arabinoside. The sensitivity of th...

Marrow specimens obtained from 23 patients with acute myelocytic leukemia were exposed to cytosine arabinoside and/or daunorubicin in vitro, and the effects of these agents on colony formation in vitro was determined. Thymidine suicide indices were determined as well, which permitted a distinction to be made between kinetic and metabolic resistance to cytosine arabinoside. The sensitivity of th...

In a retrospective analysis five of 104 patients with acute leukaemia undergoing cytotoxic chemotherapy developed abdominal signs requiring emergency surgical exploration. Two common features in these patients were the inclusion of cytosine arabinoside in their treatment regimen and a necrotizing lesion involving the terminal ileum, appendix, and right colon. Appendicectomy was performed in two...

The rate of DNA synthesis was determined in rats with developing and established two-kidney, one clip renal hypertension. Rate of DNA synthesis was measured as [3H]thymidine incorporation into DNA per hour. After stenosis of the renal artery, blood pressure increased over a 2-week period. Five days after clipping, there was an increase in the rate of aortic DNA synthesis before an increase in b...

The epithelial cells from mammary glands of mature virgin mice synthesize increasing levels of casein and cY-lactalbumin when cultured in the presence of insulin, hydrocortisone, and prolactin. When DNA synthesis is blocked in these cultures by the addition of cytosine arabinoside or 5-fluorodeoxyuridine, augmented milk-protein production does not occur. The effects of cytosine arabinoside are ...

Cytosine arabinoside and Methotrexate alter in different ways the metabolic patterns of leukocytes from patients with acute granulocytic leukemia. The variations in the incorpora tion into DNA of deoxyuridine and thymidine during the first twenty-four hours after cytosine arabinoside administration were correlated with one another but not with the variation in activity of thymidylate synthetase...

OBJECTIVE To determine the gastrointestinal toxic effects of idarubicin and cytosine arabinoside combination therapy in patients with newly diagnosed acute myelogenous leukemia (AML). PATIENTS AND METHODS We performed a single-institution retrospective analysis of the incidence of neutropenic colitis in patients with newly diagnosed AML receiving idarubicin and cytosine arabinoside combinatio...