Here we analyze the essential process of X-chromosome dosage compensation (DC) to elucidate mechanisms that control the assembly, genome-wide binding, and function of gene regulatory complexes that act over large chromosomal territories. We demonstrate that a subunit of Caenorhabditis elegans MLL/COMPASS, a gene activation complex, acts within the DC complex (DCC), a condensin complex, to targe...

Lifecycle management of digital materials can help conceptualisation of the stages required to successfully curate digital material. A number of discipline specific models, and more generally applicable standards, have been developed which can be used as a basis when planning and implementing organisational management of digital material. The generic Draft DCC Curation Lifecycle Model identifie...

In many species, a dosage compensation complex (DCC) is targeted to X chromosomes of one sex to equalize levels of X-gene products between males (1X) and females (2X). Here we identify cis-acting regulatory elements that target the Caenorhabditis elegans X chromosome for repression by the DCC. The DCC binds to discrete, dispersed sites on X of two types. rex sites (recruitment elements on X) re...

We consider the quantum state describing the Disoriented Chiral Condensate (DCC), which may be produced in high energy collisions. We show how a mean eld treatment of the quantum equations corresponding to the classical linear sigma model leads to a squeezed state description of the pions emerging from the DCC. We examine various squeezed and coherent state descriptions of those pions with part...

Social networks, such as virtual communities, permit connections between citizen and government. Integrating consultative and deliberative environments for popular participation in democratic issues and creating virtual communities for warranting better relationship among members make it possible to model decisionmaking processes. For this reason, the Democratic Citizenship Community (DCC) was ...

The cells expressing the T674I point mutant of FIP1-like-1-platelet-derived growth factor receptor alpha (FIP1L1-PDGFRα) in hypereosinophilics syndrome (HES) are resistant to imatinib and some second-generation tyrosine kinase inhibitors (TKIs). There is a desperate need to develop therapy to combat this acquired drug resistance. DCC-2036 has been synthesized as a third-generation TKI to combat...

Relativistic nuclear collisions can produce matter in which chiral symmetry is restored. One possible consequence of this restoration is the formation of disoriented chiral condensates (DCC) – transient regions in which the average chiral order parameter differs from its value in the surrounding vacuum. Previous efforts to describe DCC signals have focused on pion production. In Ref. [1], Gavin...