نتایج جستجو برای: death receptor pathway
تعداد نتایج: 1083248 فیلتر نتایج به سال:
Introduction: Major depressive disorder is often associated with suicidal tendencies, and this condition accentuates the need for rapid-acting antidepressants. We previously reported that alkaloids (ALK) from Trichilia monadelpha possess antidepressant action in acute animal models of depression and that this effect is mediated through the monoamine and L-arginine-NO-cGMP pathways. This study i...
Ab binding to CD20 has been shown to induce apoptosis in B cells. In this study, we demonstrate that rituximab sensitizes lymphoma B cells to Fas-induced apoptosis in a caspase-8-dependent manner. To elucidate the mechanism by which Rituximab affects Fas-mediated cell death, we investigated rituximab-induced signaling and apoptosis pathways. Rituximab-induced apoptosis involved the death recept...
Phenylketonuria (PKU), an autosomal recessive disorder of amino acid metabolism caused by mutations in the phenylalanine hydroxylase (PAH) gene, leads to childhood mental retardation by exposing neurons to cytotoxic levels of phenylalanine (Phe). A recent study showed that the mitochondria-mediated (intrinsic) apoptotic pathway is involved in Phe-induced apoptosis in cultured cortical neurons, ...
Apoptosis is initiated via the mitochondrial or the death receptor pathway. Central to the mitochondrial pathway is the release of cytochrome c from the mitochondria, leading to activation of the caspase cascade and execution of apoptosis.1 The mitochondrial pathway is regulated by the BCL-2 family of proteins, i.e. proapoptotic BAX and BAK as well as antiapoptotic BCL-2 and BCL-xL. The death r...
Necroptosis, as a novel concept, has been recently introduced in scientific literature. Much of our knowledge about necroptosis comes from ligation of tumor necrosis factor-α to its receptor, TNF receptor 1. Receptor-interacting protein kinase 1, receptor-interacting protein kinase 3 and its substrate, the pseudokinase mixed lineage kinase domain-like protein, have been comprehensively st...
Apoptin, a small proline-rich protein derived from the chicken anaemia virus, induces cell death selectively in cancer cells. The signalling pathways of apoptin-induced, cancer cell-selective apoptosis are not well understood. Here, we demonstrate that apoptin triggers apoptosis by activating the mitochondrial/intrinsic pathway, and that it acts independently of the death receptor/extrinsic pat...
long-term potentiation (ltp) is a process that certain types of synaptic stimulation lead to a long-lasting enhancement in the strength of synaptic transmission. studies in recent years indicate the importance of molecular pathways in the development of memory and learning. tropomyosin receptor kinase b (trkb) is a member of the neurotrophin receptor tyrosine kinase family, that its ligand is b...
The p75 neurotrophin receptor (p75(NTR)) belongs to the tumor necrosis factor receptor/nerve growth factor receptor superfamily. In some cells derived from neuronal tissues it causes cell death through a poorly characterized pathway. We developed a neuronal system using conditionally immortalized striatal neurons, in which the expression of p75(NTR) is inducibly controlled by the ecdysone recep...
Background: Necroptosis is a novel programmed cell death pathway proposed in 2005, which mainly activated by the tumor necrosis factor (TNF) family and mediates cellular disassembly via receptor interacting serine/threonine kinase 1 (RIPK1), 3 (RIPK3) mixed lineage domain like pseudokinase (MLKL). We tried to analyze relationship of necroptosis-related genes (NRGs) expression with colon adenoca...
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