Background and Objective: Several studies have found that diazepam decreases serum glucose. Meanwhile, glibenclamide is commonly used in diabetes treatment. The objective of this study was to survey the treatment impact of diazepam and glibenclamide on blood glucose and serum lipids in mice with type II diabetes. Materials and Methods: In this study, 32 male rats were divided into four groups,...

Benzodiazepines ameliorate or prevent the symptoms and complications of moderate to severe alcohol withdrawal, which can include autonomic hyperactivity, agitation, combativeness, hallucinations, seizures, delirium, and death. The benzodiazepines most commonly used for this purpose are lorazepam, chlordiazepoxide, oxazepam, and diazepam. It is widely asserted that no member of this group is sup...

Ganaxolone (3alpha-hydroxy-3beta-methyl-5alpha-pregnane-20-one), an orally active synthetic analog of the neuroactive steroid allopregnanolone, is a positive allosteric modulator of gamma-aminobutyric acid(A) receptors with anticonvulsant properties. We sought to determine whether tolerance occurs to the anticonvulsant activity of ganaxolone in the pentylenetetrazol seizure test and whether the...

PURPOSE This study was undertaken to compare the effectiveness of oral diazepam and midazolam in sedating autistic patients during dental treatment. METHODS The treatment regimen consisted of nitrous oxide/oxygen inhalation in conjunction with oral administration of either diazepam 0.3 mg/kg or midazolam 0.5 mg/kg in a cross-over design study of 13 subjects aged 5.8 to 14.7 years. A drug was ...

The absorption of diazepam after rectal administration was studied in children with epilepsy. When given as a solution, diazepam was rapidly absorbed and produced serum diazepam concentrations above 200 ng/ml within 10 minutes in most children. However, a commercial suppository formulation was absorbed slowly and cannot be recommended for urgent treatment of fits. There is a need in the UK for ...

background: febrile convulsion (fc) is one of the most common causes of seizure in children. oral diazepam or oral midazolam are two mostly recommended drugs for fc prevention, but the effectiveness of these drugs remains controversial. prophylactic use of oral anticonvulsant drugs is thus a questionable practice. this study was carried out to compare the effect of using different diazepam dose...

A total of 90 patients including 30 patients of generalized anxiety disorder and 30 of dysthymic disorder according to DSM III criteria plus 30 patients of mixed anxiety-depressive disorder were given a detailed psychiatric evaluation and four rating scales were made for measuring the level of anxiety and depression at intake and to record their improvement with treatment. Half the subjects in ...

The synaptogenic hypothesis of major depressive disorder implies that preventing the onset depressive-like behavior also prevents loss hippocampal spine synapses. By applying psychoactive drugs, diazepam and fluoxetine, we investigated whether blocking development helpless by promoting stress resilience in rat learned helplessness paradigm is associated with a synaptoprotective action hippocamp...

Introduction: To improve our understanding of dizziness, its assessment, as well as its management to identify the appropriate treatment in order to reduce the costs and to increase the patients’ quality of life. Methods: A single blind parallel group randomized controlled trial was conducted on 164 participants with dizziness. One group received 25mg/ml promethazine and another received 5mg/ml...

The in utero exposure of hamsters to low doses of diazepam results in impaired host defense against Mycobacterium bovis during adulthood. Delayed developmental immunotoxicity, however, represents a specific situation that might not be general. The present experiment was undertaken to investigate the effects of diazepam on hamster resistance to M. bovis using adult animals. The effects of diazep...