OBJECTIVE To evaluate anterior cruciate ligament transection (ACLT) and destabilization of the medial meniscus (DMM) surgical instability models of osteoarthritis (OA) in the 129/SvEv mouse knee joint. DESIGN Micro-surgical techniques were used to perform ACLT or DMM under direct visualization. Histological scoring was performed on multiple sections to assess cartilage damage across the entir...

It is difficult to distinguish desmoplastic malignant mesothelioma (DMM) from fibrous pleuritis (FP). We investigated the utility of immunohistochemistry as a way of differentiating between DMM and FP. We examined 11 DMMs and 46 FPs with the aid of antibodies against 18 cytokeratin (CK) subtypes, calponin, caldesmon, desmin, and GLUT-1. The best sensitivity and specificity cut-off values in the...

1, Methods The DMM was designed to measure light sensitivity threshold to a white stimuli at 100 locations on a 5” region of 1” resolution at the lmacula using Humphrey Field Analyzer-640 in 24 eyes of the normal elderly. The age range was 50-69. The test of routine threshold programma 10-2 was compared. The statistical analysis was carried out for measurements. Results There were no significan...

1, Methods The DMM was designed to measure light sensitivity threshold to a white stimuli at 100 locations on a 5” region of 1” resolution at the lmacula using Humphrey Field Analyzer-640 in 24 eyes of the normal elderly. The age range was 50-69. The test of routine threshold programma 10-2 was compared. The statistical analysis was carried out for measurements. Results There were no significan...

The dorsomedial medulla oblongata (DMM) includes the solitary tract nucleus and the hypoglossal nucleus, to which 5-HT neurons project. Effects of 5-HT in the DMM on ventilatory augmentation and airway dilation are mediated via 5-HT2 receptors, which interact with the CO(2) drive. The interaction may elicit cycles between hyperventilation with airway dilation and hypoventilation with airway nar...

Diffuse malignant mesothelioma (DMM) is a tumor of serosal membranes with propensity for progressive local disease. Because current treatment options are largely ineffective, novel therapeutic strategies based on molecular mechanisms and the disease characteristics are needed to improve the outcomes of patients with this disease. Akt kinase interacting protein 1 (Aki1; Freud-1/CC2D1A) is a scaf...

1, Methods The DMM was designed to measure light sensitivity threshold to a white stimuli at 100 locations on a 5” region of 1” resolution at the lmacula using Humphrey Field Analyzer-640 in 24 eyes of the normal elderly. The age range was 50-69. The test of routine threshold programma 10-2 was compared. The statistical analysis was carried out for measurements. Results There were no significan...

1, Methods The DMM was designed to measure light sensitivity threshold to a white stimuli at 100 locations on a 5” region of 1” resolution at the lmacula using Humphrey Field Analyzer-640 in 24 eyes of the normal elderly. The age range was 50-69. The test of routine threshold programma 10-2 was compared. The statistical analysis was carried out for measurements. Results There were no significan...

5-HT2 receptor activity in the hypoglossal nucleus and hypercapnia is associated with airway dilation. 5-HT neurons in the medullary raphe and hypercapnia are responsible for tidal volume change. In this study, the effects of 5-HT2 receptors in the dorsomedial medulla oblongata (DMM), which receives projections from the medullary raphe, and hypercapnia on airway resistance and respiratory varia...

Dynamic Meta Modeling (DMM) is a universal approach to defining semantics for languages syntactically grounded on meta models. DMM has been designed with the aim of getting highly understandable yet precise semantic models which in particular allow for a formal analysis. In this paper, we exemplify this by showing how DMM can be used to give a semantics to and define an associated analysis tech...