to inform healthcare professionals of a rare serious reaction leading to leg amputation following intramuscular injection of iron dextran and report comments for preventing such reactions.a case of leg amputation following intramuscular injection of iron dextran reported to iranian pharmacovigilance center was reviewed. patient and reaction data was collected by assessing the reported yellow ca...

evidence acquisition medline, pubmed, ovid and embase were used to search for clinical studies comparing with or without prophylactic use of lamivudine for hbv reactivation in breast cancer patients receiving chemotherapy. outcomes of interest were the rate of hbv reactivation, incidence of hepatitis and incidence of hepatitis attributable to hbv reactivation, severity of hepatitis and severity...

Physicians prescribe drugs to prevent or treat disease. Those same drugs can be toxic to certain patients, however, because of genetic predisposition, nonselective action, or inappropriate use or administration of the drug. The United States Food and Drug Administration (FDA) spends a significant portion of its $1 trillion budget to ensure that new drugs are not overtly or unnecessarily dangero...

background:methotrexate (mtx) is one of the most commonly used disease-modifying antirheumatic drugs in the treatment of rheumatoid arthritis (ra) which can be associated with toxic effects on different organs. this study was designed to investigate the hepatotoxic effects in ra patients treated with mtx. methods: in this cross-sectional observational study, ra patients who received standard do...