Transplantation therapy for humans is limited by insufficient availability of donor organs and outcomes are complicated by the toxicity of immunosuppressive drugs. Xenotransplantation is a strategy to overcome supply problems. Implantation of tissue obtained early during embryogenesis is a way to reduce immunogenicity of transplants. Insulin-producing cells originating from embryonic pig pancre...

The registration and approval of novel medicines have traditionally been based on evidence arising from large prospective trials. Such an approach is often not possible or unsuitable to evaluate the benefit-risk balance in special populations (e.g., children, ethnic groups, rare diseases). Inferences by modeling and simulation can play a major role in evidence synthesis. A framework is proposed...

Abstract The BBM equation is a Hamiltonian PDE which revealed to be very interesting test-model study the transformation property of Gaussian measures along flow, after Tzvetkov (Sigma 3:e28-35). In this paper we with critical dispersion (which Benjamin-Ono type model). We prove that image supported on fractional Sobolev spaces increasing regularity are absolutely continuous, but cannot identif...

From Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom. Disclosures: None. Received for publication March 26, 2008; revisions received June 5, 2008; accepted for publication Sept 1, 2008; available ahead of print Jan 27, 2009. Address for reprints: Prem Venugopal, MCh, FRCS, Department of cardiac Surgery, East wing, St Thomas’ Hospital, Lambeth Palace Rd, London SE1 7EQ, United ...

The Seebeck coefficient of p-type PbTe can be enhanced at 300 K, either due to the addition of Tl-resonant states or by manipulation of the multiple valence bands by alloying with isovalent compounds, such as MgTe. PbTe alloyed with MnTe shows a similar thermopower enhancement that could be due to either mechanism. Here we investigate the characteristics that distinguish the resonant state mech...

ferential expression of novel potential regulators in hematopoietic stem cells. PLoS Genet (http://genetics.plosjournals.org/). 2005;1:e28. Accessed January 8, 2008. 5. Pronk CJH, Rossi DJ, Månsson R, et al. Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy. Cell Stem Cell. 2007;1:428-442. 6. Chambers SM, Boles NC, Lin KK, et al. H...

Transplantation therapy for diabetes is limited by unavailability of donor organs and outcomes complicated by immunosuppressive drug toxicity. Xenotransplantation is a strategy to overcome supply problems. Implantation of tissue obtained early during embryogenesis is a way to reduce transplant immunogenicity. Insulin-producing cells originating from embryonic pig pancreas obtained very early fo...

Transplantation therapy for diabetes in humans is limited by the low availability of human donor whole pancreas or islets. Outcomes are complicated by immunosuppressive drug toxicity. Xenotransplantation is a strategy to overcome supply problems. Implantation of tissue obtained early during embryogenesis is a way to reduce transplant immunogenicity. Pig insulin is biologically active in humans....