Embryonic day (E) 28 (E28) pig pancreatic primordia transplanted into the mesentery of non-immunosuppresed steptozotocin (STZ)-diabetic Lewis rats normalize levels of circulating glucose within 2-4 weeks. Exocrine tissue does not differentiate after transplantation of pancreatic primordia. Rather individual endocrine (beta) cells engraft within the mesentery.To determine whether transplanted pi...

Transplantation therapy for human diabetes is limited by the toxicity of immunosuppressive drugs. If toxicity can be minimized, there will still be a shortage of human donor organs. Xenotransplantation of porcine islets is a strategy to overcome supply problems. Xenotransplantation in mesentery of pig pancreatic primordia obtained very early during organogenesis [embryonic day 28 (E28)] is a wa...

Lack of donor availability limits the number of human donor organs. The need for host immunosuppression complicates transplantation procedures. Ultrastructurally precise kidneys differentiate in situ following xenotransplantation in mesentery of embryonic pig renal primordia. The developing organ attracts its blood supply from the host, obviating humoral rejection. Engraftment of pig renal prim...

Cells expressing doublecortin (DCX+) occur at cortical layer II, predominantly over the paleocortex in mice/rats, but also across the neocortex among larger mammals. Here, we explored the time of origin of these cells in neonatal and 2-month-old guinea pigs following prenatal BrdU pulse-chasing. In the neocortex, BrdU+ cells birth-dated at embryonic day 21 (E21), E28, and E35 laminated over the...

Transplantation therapy for diabetes is limited by unavailability of donor organs and outcomes complicated by immunosuppressive drug toxicity. Xenotransplantation is a strategy to overcome supply problems. Implantation of tissue obtained early during embryogenesis is a way to reduce transplant immunogenicity. Insulin-producing cells originating from embryonic pig pancreas obtained very early fo...

In mammalian cerebrum there exist two distinct types of interneurons expressing nitric oxide synthase (NOS). Type I neurons are large in size and exhibit heavy nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) histochemical reaction, while type II cells are small with light NADPH-d reactivity. The time of origin of these cortical neurons relative to corticogenesis remains largely...

P. Manz, G. Birkenmeier, G. Fuchert, M. Cavedon, G.D. Conway, M. Maraschek, A. Medvedeva F. Mink, B.D. Scott, L.M. Shao, U. Stroth and the ASDEX Upgrade Team 1 Physik-Department E28, Technische Universität München, James-Franck-Str. 1, 85748 Garching, Germany 2 Max-Planck-Institut für Plasmaphysik, Boltzmannstr.2 ,85748 Garching, Germany 3 Institute of Plasma Physics, Chinese Academy of Science...

In this study, we sequenced the complete genome of the multidrug-resistant Escherichia coli strain E28, which was used as an indicator strain for phage therapy in vivo We used a combination of single-molecule real-time and Illumina sequencing technology to reveal the presence of a spontaneously inducible prophage.

0127 January 2007 | Volume 5 | Issue 1 | e3 | e28 Correction: Asymmetrical Reinforcement and Wolbachia Infection in Drosophila John Jaenike, Kelly Dyer, Chad Cornish, Miranda Minhas doi:10.1371/journal.pbio.0040325 In PLoS Biology, volume 4, issue 10: The “female population” part of the x-axis label in Figure 2 has an error: the labels sym and allo are switched in two places. Attached is a PDF ...