نتایج جستجو برای: eae model

تعداد نتایج: 2106206  

Journal: :Journal of Immunology 2023

Abstract Multiple sclerosis (MS), an autoimmune disease of the central nervous system, is thought to be mediated by autoreactive CD4+ T cells producing IL-17A and IFNg. However, it unclear if these cytokines are essential for development, progression, or both. We have shown that neither IFNg nor IL-17A, alone, required development in experimental encephalomyelitis (EAE), a mouse model MS, but a...

Akbar Karimi, Farhad Ahmadi, Hossein Afrouzi Kazem Parivar Mohammad Nabiuni Saied Haghighi Sohrab Imani

   Multiple sclerosis (MS) is a progressive and autoimmune neurodegenerative disease of the central nervous system (CNS). This disease is recognized through symptoms like inflammation, demyelination and the destruction of neurological actions. Experimental allergic encephalomyelitis (EAE) is a widely accepted animal model for MS. EAE is created in animals by injecting the tissue of myelin basic...

Akbar Karimi, Farhad Ahmadi, Hossein Afrouzi Kazem Parivar Mohammad Nabiuni Saied Haghighi Sohrab Imani

   Multiple sclerosis (MS) is a progressive and autoimmune neurodegenerative disease of the central nervous system (CNS). This disease is recognized through symptoms like inflammation, demyelination and the destruction of neurological actions. Experimental allergic encephalomyelitis (EAE) is a widely accepted animal model for MS. EAE is created in animals by injecting the tissue of myelin basic...

Journal: :European Journal of Immunology 2009

Journal: :iranian biomedical journal 0
abbas ebrahimi-kalan jafar soleimani rad laya kafami daryoush mohammadnejad mehryar habibi roudkenar amir afshin khaki

background: experimental autoimmune encephalomyelitis (eae) is an animal model of multiple sclerosis, which is a demyelinating and an inflammatory disease of central nervous system. recent studies have established that some molecules such as lipocaline2 (lcn2), which expresses during inflammatory conditions, play an important role in eae pathogenesis and might involve in its treatment process. r...

2017
Jordon Dunham Reinofke van de Vis Jan Bauer Jacqueline Wubben Nikki van Driel Jon D Laman Bert A 't Hart Yolanda S Kap

Oxidative stress is increasingly implicated as a co-factor of tissue injury in inflammatory/demyelinating disorders of the central nervous system (CNS), such as multiple sclerosis (MS). While rodent experimental autoimmune encephalomyelitis (EAE) models diverge from human demyelinating disorders with respect to limited oxidative injury, we observed that in a non-human primate (NHP) model for MS...

ژورنال: :iranian red crescent medical journal 0
abbas ebrahimi kalan anatomical sciences department, school of medicine, tabriz university of medical sciences, tabriz, ir iran; shefa neuroscience research center, tehran, ir iran jafar soleimani rad anatomical sciences department, school of medicine, tabriz university of medical sciences, tabriz, ir iran laya kafami shefa neuroscience research center, tehran, ir iran; pathobiology department, school of medicine, alborz university of medical sciences, karaj, ir iran daryoush mohamadnezhad anatomical sciences department, school of medicine, tabriz university of medical sciences, tabriz, ir iran amir afshin khaki anatomical sciences department, school of medicine, tabriz university of medical sciences, tabriz, ir iran amaneh mohammadi roushandeh anatomical sciences department, school of medicine, tabriz university of medical sciences, tabriz, ir iran; anatomical sciences department, school of medicine, hamedan university of medical sciences, hamedan, ir iran; anatomical sciences department, school of medicine, hamedan university of medical sciences, hamedan, ir iran. tel: +98-9143078216, fax: +98-8118380208

background cytokines are secreted signaling proteins which play essential roles in immune responses during experimental autoimmune encephalomyelitis (eae), a demyelinating model that mimics many features of multiple sclerosis (ms). interleukin 6 (il-6) is a multifunctional cytokine produced by different cells, mediating inflammatory reactions and immune-mediated processes. several studies have ...

2013
Manmohan Singhal Parul Srivastava

Experimental autoimmune encephalomyelitis (EAE) is the most widely accepted in vivo animal model of Multiple sclerosis (MS). EAE model are most suitable for analysis of immunogenetic elements (major histocompatibility complex) and for the study of histological features (inflammation, demyelination and degeneration) of the disease for screening of new treatments for MS. Some approved medications...

Abbas Ebrahimi-Kalan, Amaneh Mohammadi Roushandeh, Amir Afshin Khaki, Daryoush Mohammadnejad, Jafar Soleimani Rad, Laya Kafami, Mehryar Habibi Roudkenar, Zeynab Aliyari Serej,

Background: Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis, which is a demyelinating and an inflammatory disease of central nervous system. Recent studies have established that some molecules such as Lipocaline2 (LCN2), which expresses during inflammatory conditions, play an important role in EAE pathogenesis and might involve in its treatment process. ...

شفیع مجددی, محمد, محمدزاده, محمد, محمودآبادی, نجمه, گل محمدی, رحیم,

Background and purpose: Using allogeneic and xenogeneic mesenchymal stem cells (MSCs) has had some successful results in the treatment of experimental autoimmune encephalomyelitis (EAE). But the use of its syngeneic counterparts in treatment of EAE, especially established EAE, has had some paradoxical results. This study aimed to evaluate the therapeutic potential of syngeneic bone marrow-deriv...

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