نتایج جستجو برای: epithelial neoplasia
تعداد نتایج: 180290 فیلتر نتایج به سال:
BACKGROUND Use of the conventional Western and Japanese classification systems of gastrointestinal epithelial neoplasia results in large differences among pathologists in the diagnosis of oesophageal, gastric, and colorectal neoplastic lesions. AIM To develop common worldwide terminology for gastrointestinal epithelial neoplasia. METHODS Thirty one pathologists from 12 countries reviewed 35...
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease. Although rigorous efforts identified the presence of ‘cancer stem cells (CSCs)’ in PDAC and molecular markers for them, cell dynamics vivo have not been clearly demonstrated. Here we focused on Doublecortin-like kinase 1 (Dclk1), known as CSC marker PDAC. Using genetic lineage tracing with dual-recombinase system live imaging, sh...
Background: The most common clinical types of gestational trophoblastic neoplasia are invasive hydatidiform mole and choriocarcinoma, which can be diagnosed without pathology, cured by chemotherapy. Epithelial tumor, a rare type neoplasia, does not exhibit precise manifestations upon auxiliary examinations. Therefore, since epithelial tumors prone to misdiagnoses missed diagnoses, their diagnos...
Introduction. Gestational trophoblastic disease represents a distinguished group of disorders that are derived from placental tissue aroused abnormal fertilization. Choriocarcinoma is malignant human chorionic gonadotropin-producing epithelial tumor arising villous trophoblast. The choice the chemotherapy regime based on International Federation Gynecology and Obstetrics stage World Health Orga...
BACKGROUND The pathogenesis for colorectal cancer remains unresolved. A growing body of evidence suggests a direct correlation between cyclooxygenase enzyme expression, prostaglandin E2 metabolism and neoplastic development. Thus further understanding of the regulation of epithelial functions by prostaglandin E2 is needed. We hypothesized that patients with colonic neoplasia have altered coloni...
Background and Aims: Ovarian cancer is one of most common causes of cancer related women's mortalities. Human papilloma virus is a known factor concerning cervical cancer but its role in causing ovarian cancer is not yet verified. A few studies also identified HPV DNA in ovarian carcinoma tissues. However, some studies did not detect HPV DNA in ovarian carcinoma tissues. In this articl...
Neoplastic transformation of human epithelial cells in vitro after exposure to chemical carcinogens.
Human foreskin epithelial cells were transformed to an anchorage-independent state of growth (in soft agar) and neoplasia (invasion of chick embryonic skin in vitro). Aflatoxin B1, N-methyl-N'-nitro-N-nitrosoguanidine, propanesultone, beta-propiolactone, or ultraviolet absorbance at 254 nm were used successfully as carcinogens. These foreskin epithelial cells, like human foreskin fibroblasts, w...
Only select cell types in an organ display neoplasia when targeted oncogenically. How developmental lineage hierarchies of these cells prefigure their neoplastic propensities is not yet well-understood. Here we show that neoplastic Drosophila epithelial cells reverse their developmental commitments and switch to primitive cell states. In a context of alleviated tissue surveillance, for example,...
ocular surface may be involved by different neoplastic lesions ranging from benign to highly malignant. recognition of risk factors, clinical presentations, pathology, and different therapeutic modalities is essential for selecting an appropriate approach. this article deals with the proper approach to ocular surface squamous neoplasia (ossn) including conjunctival/corneal intraepithelial neopl...
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