RATIONALE The decline in estrogen concentrations in women after menopause can contribute to health related changes including impairments in cognition, especially memory. Because of the health concerns related to hormone replacement therapy (HRT), alternative approaches to treat menopausal symptoms, such as nutritional supplements and/or diet containing isoflavones, are of interest. OBJECTIVES...

Studies of hypervitaminosis A in animals and anecdotal reports of accidental vitamin A poisoning in humans suggest impairment of bone remodeling and increased numbers of fractures. Because of the widespread use of high-dose vitamin A supplements which may produce subclinical hypervitaminosis associated with decreased bone mass and increased risk of fracture, we studied the relationship between ...

Polycystic ovary syndrome (PCOS) is a complex and heterogeneous disorder that affects large percentage of women worldwide. The pathophysiology not fully explained. In recent years, complementary alternative medicine has emerged as viable treatment option. This study examined how curcumin zinc affected on reproductive hormones in rats with polycystic (PCOS). It was induced by oral administration...

BACKGROUND In human, a reduction in estrogen has been proposed as one of the key contributing factors for postmenopausal osteoporosis. Rodents are conventional models for studying postmenopausal osteoporosis, but the major limitation is that ovariectomy is needed to mimic the estrogen decline after menopause. Interestingly, in medaka fish (Oryzias latipes), we observed a natural drop in plasma ...

BACKGROUND The immune system may be compromised after menopause because of the effects of aging and diminishing concentrations of estrogen, an immune-modulating hormone. Isoflavones, plant-derived compounds with estrogenic and antioxidant properties, may offer immunologic benefits to women during this stage of life. OBJECTIVE The objective of this study was to evaluate the effects of soy isof...

In this study, 44 Afshari ewes were investigated that 1–4 years old with a mean weight of 54–51 kg, physical score approximately three in four experimental groups. Ewes randomly assigned into groups including Group A Control (base diet recipient), B (Flushing), C (Flushing + Vitamin E Supplement Organic Selenium), and D Mineral Selenium). Blood sampling was carried out at different intervals na...

In estrogen-induced, estrogen-dependent, mammary and adrenocorlical carcinomas, the specific activities of t lie tliymidine kinasc and thymidylate kinase decreased significantly within 2 to 4 days after removal of the source of estrogen of the host. After 7 days, these changes were even more marked in the adrenal tumors. Similar changes were not observed in the activity of these enzymes in auto...

Abstract Purpose: With rapid advancements in therapeutic options for patients with cystic fibrosis (CF), the median predicted survival has increased to 47 years along prevalence of non-pulmonary complications CF. Women CF suffer irregular menses, sexual dysfunction and low bone mineral density. increasing pregnancies among women CF, they may consider contraception. Estrogen supplementation modu...