Bacteria that simultaneously produce multiple extended-spectrum beta-lactamases are frequently isolated. We report an Enterobacter cloacae isolate, ES24, producing four different beta-lactamases (AmpC type beta-lactamase, TEM-1, SHV-7, and a novel extended-spectrum beta-lactamase, SHV-30). Direct sequencing of bla(SHV) gene products gave a "double peak" at position 703, suggesting the presence ...

conclusions our study showed that the prevalence of esbl-producing k. pneumoniae at king khalid hospital was significantly high. routine detection of esbl-producing microorganisms is required by each of the laboratory standard detection methods to control the spread of these infections and allow a proper therapeutic strategy. for detection, the phenotypic confirmatory disc diffusion test is sim...

introduction: extended spectrum beta-lactamase (esbl) producing escherichia coli generate a major problem for clinical therapeutics and epidemiological study. the incidence of esbl producing strains among clinical isolates has been steadily increasing during the past few years, and remains an important cause of failure of therapy with cephalosporins. the aim of this study was to determine the a...

BACKGROUND The aims of this study were to confirm the presence of OmpK35 and OmpK36 in extended-spectrum beta-lactamase-producing and nonextended-spectrum beta-lactamase-producing Klebsiella pneumoniae and to determine the relationship between porin expression and resistance to third-generation cephalosporins. METHODS Fifty-two K. pneumoniae isolates were obtained and analyzed for extended-sp...

Antimicrobial resistance (AMR) occurs when microorganisms fail to respond the therapeutic onslaught of antibiotics. Extended-spectrum beta-lactamase (ESBL) and AmpC enzymes are important AMR mechanisms that erode efficacy Here, we report on detection susceptibility ESBL- AmpC-producing bacteria from livestock poultry environments. Bacteriological molecular biology tools were used for isolation ...

background urinary tract infections (uti) caused by resistant bacteria are becoming more prevalent. the spread of extended-spectrum beta-lactamase (esbl)-producing bacteria worldwide has become a serious public health issue among healthcare centers and in the community. drugs and many secondary metabolites from medicinal plants have proved to be economical and effective against many pathogens. ...

background klebsiella pneumoniae is a family member of enterobacteriaceae. isolates of k. pneumoniae produce enzymes that cause decomposition of third generation cephalosporins. these enzymes are known as extended-spectrum beta-lactamase (esbl). resistance of k. pneumoniae to beta-lactamase antibiotics is commonly mediated by beta-lactamase genes. objectives the aim of this study was to identif...

BACKGROUND Knowledge of the clinical features of infections caused by Escherichia coli strains that produce plasmid-mediated AmpC beta-lactamase is limited. Of the several groups of plasmid-mediated AmpC beta-lactamases, CMY-type beta-lactamase is the most common in the United States. METHODS We prospectively identified patients infected or colonized with E. coli strains that produce CMY-type...