نتایج جستجو برای: familial cancer
تعداد نتایج: 958449 فیلتر نتایج به سال:
Background and Aim: The aim of this study is to evaluate the familial aggregation of esophageal cancer in a defined population under coverage of Babol Research Station, Institute of Public Health Research, Tehran University of Medical Sciences, in one of the high incidence areas in north of Iran and to assess the risk of disease associated with first degree familial relationship. Material and ...
Background and Purpose: Each year, about 50,000 new cases of cancer occur in Iran and the most common being the gastrointestinal (GI) tract (38%). Colorectal cancers account for the 3rd and 4th most prevalent cancers in Iranian men and women, respectively. Since genetic and environmental factors lead to differences in colorectal cancer occurrence in different geographic regions and races, we ...
Background: Hormones and genetics play a critical role in breast cancer development, determining the association between plasma hormones and breast cancer risk among familial and non-familial females may provide insight into the etiology of breast cancer. Material and Methods: 140 postmenopausal females during the period between June 2007 and May 2011 were enrolled in this study, 83 were breast...
Background: The aim of this study was to investigate the relationship of familial history of gastrointestinal cancers and personal history of colon polyps with colorectal cancer incidence in khorramabad in 2012. Materials and Methods: This cross-sectional study included 50 patients with definite diagnosis of colon cancer based on colonoscopy and pathology in 2012. The control group included 56 ...
introduction: pathophysiology of cancer is based on genetic instabilities. this can explain recent important role of genetic studies in such diseases. defects can be large (on molecular scale) at the level of chromosomal or small in nucleotide level, which eventually causes to irreversible change in the cell. conventional technical methods in cancer genetics are generally based on molecular or ...
Familial cancer clustering, without obvious heritability, poses a major challenge for current cancer risk assessment and management. Reliable determination of familial risks for cancer is important for clinical genetic counselling, but medically verified data on familial risks for many malignancies have been limited. However, the nationwide Swedish Family-Cancer Database allows a reliable chara...
absract gastric cancer is the fourth most common cancer and the second leading cause of cancer death. most cases are sporadic and only 10% of patients, show familial clustering. among these patients, 1 to 3 % have hereditary diffuse gastric cancer (hdgc), which is autosomal-dominant and present in younger ages. mutations in ecadherin gene cdh1 has been identified in 30 to 50% of patients. becau...
Familial follicular cell-derived well-differentiated thyroid cancer, papillary (PTC), and follicular thyroid carcinomas (FTC), accounts for 95% of thyroid malignancies. The majority of are sporadic, and at least 5% of these patients will have familial disease. Familial thyroid syndromes are classified into familial medullary thyroid carcinoma (FMTC), derived from calcitonin-producing C cells, a...
The contribution of BRCA1 and BRCA2 to familial and non-familial forms of breast cancer has been difficult to accurately estimate because of the myriad of potential genetic and epigenetic mechanisms that can ultimately influence their expression and involvement in cellular activities. As one of these potential mechanisms, we investigated whether allelic imbalance (AI) of BRCA1 or BRCA2 expressi...
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