An uncommon case of undifferentiated carcinoma of the gall bladder in a 65 year old Chinese man, who presented with an increased serum alpha-fetoprotein concentration, is reported. Histologically, the tumour had a primitive appearance and was composed of a pavement-like array of poorly differentiated columnar/polygonal cells. Alpha-fetoprotein was demonstrated in some of the tumour cells using ...

INTRODUCTION Preoperative serum alpha-fetoprotein levels can have predictive value for hepatocellular carcinoma survival. AIM Our aim was to analyze the correlation between preoperative serum alpha-fetoprotein levels and survival, following the surgical treatment of hepatocellular carcinoma. METHODS Nineteen patients were prospectively followed (07/2005-01/2016). An ROC curve was created to...

The inhibitory effect of human alpha-fetoprotein on the protein synthesis (incorporation of [3H]leucine into the total protein fraction) weas observed in a rabbit reticulocyte lysate cell-free system. The incorporation was inhibited to 50% of the control level by 14-16 microM alpha-fetoprotein, and decreased to about 15% at a concentration higher than 40 microM. An almost identical dose depende...

Aim. To investigate the relationship between alpha-fetoprotein and zinc fingers and homeoboxes 2 in hepatocellular carcinoma. Materials and Methods. The expressions of zinc fingers and homeoboxes 2, nuclear factor-YA, and alpha-fetoprotein mRNA in 63 hepatocellular carcinoma were detected by reverse transcriptase-polymerase chain reaction and compared with the clinical parameters of the patient...

background: prediction of severe neonatal hyperbilirubinemia is very important for early treatment and prophylaxis of neurologic sequels. the aim of this study was to evaluate the predictive role of umbilical cord ^5-fetoprotein (ucafp) as a marker of an increased risk for neonatal hyperbilirubinemia in full term babies. methods: umbilical cord blood was collected from 400 term singleton full t...

The dearth of plasma alpha fetoprotein reference ranges for preterm infants often impairs the clinical interpretation of plasma alpha fetoprotein data collected from ill babies. This study tested our hypothesis that meaningful plasma reference ranges could be established for preterm infants by a simple correction of patient age at sampling date for gestational age deficit at birth. Using a modi...

Objective: It is to detect a change in the value of alpha fetoprotein, which an indicator necroinflammation after direct effective antiviral drug therapy patients diagnosed with chronic hepatitis C.Material and Methods: In our study, data 294 who were evaluated Gastroenterology outpatient clinic Cumhuriyet University Faculty Medicine between January 2015 2020, C started direct-acting treatment,...

Alpha-fetoprotein not only serves as a diagnostic marker for liver cancer, but also posses a variety of biological functions. However, the role of Alpha-fetoprotein on tumor angiogenesis and cell invasion remains incompletely understood. In this study, we aimed to evaluate if Alpha-fetoprotein can regulate the major angiogenic factors and matrix metalloproteinases in human liver cancer cells. A...

SUMMARY The synthesis of serum a-fetoprotein was studied in 16 human embryos and fetuses between 4.2 and 18 weeks of gestation by incubation of selected tissues in l4C-labeled amino acids followed by immunoelectrophoresis of the culture fluids and radioautography. Relatively large amounts of radioactive a-fetoprotein were found in each of the liver cultures and in cultures of the developing yol...