α-Fetoprotein is a well-established tumor marker for non-seminomatous germ cell tumors. Elevated α-fetoprotein levels, however, result from a variety of clinical conditions. Hereditary persistence of α-fetoprotein is a rare benign disorder in which serum α-fetoprotein levels are persistently elevated, but there are no disabilities and symptoms. A 35-year-old man was diagnosed with pT1 testicula...

Screening examination for maternal, especially serum, is a non-invasive of the fetus’s condition. During pregnancy, screening examinations are performed in women recommended ultrasonography (USG), amniocentesis, or other obstetric interventions. There three markers maternal serum screening: alpha-fetoprotein, human chorionic gonadotropin (hCG), and unconjugated estriol. Maternal alpha-fetoprote...

Alpha-fetoprotein is an oncofetal protein the embryo produces during fetal development. The serves two critical functions simultaneously: it delivers nutrients to growing cells and immature myeloid-derived suppressor cells, so mother’s immune system doesn’t attack embryo. present in minuscule amounts adults elevated alpha-fetoprotein levels serve as pregnancy or tumor markers. Exogenous has a n...

Alpha-fetoprotein is a well-known tumor marker in the screening and follow-up of hepatocellular carcinoma. In Taiwanese society, a high prevalence of hepatitis and hepatoma and elevation of alpha-fetoprotein associated with liver function impairment usually suggested clinics undertake further examination for liver or genital tumor. We report the case of 45-year-old man who was found to have an ...

in spite of being histologically benign, sacrococcygeal teratoma (sct) may recur either as a benign or malignant tumor. a total of 26 patients with benign neonatal scts were treated in taleghanee and mofid medical centers from 1986 to 2000. investigations included radiography,abdominal ultrasound and computed tomography (ct) scan and measurement of tumor marker (α-fetoprotein). initial surgical...

We have explored immobilized metal affinity chromatography as a means of resolving alpha-fetoprotein from its homologous albumin, a problem perennially encountered in the purification of an alpha-fetoprotein or its detection. Human alpha-fetoprotein and human serum albumin were chromatographed on immobilized iminodiacetic acid charged with either Co2+, Ni2+, Cu2+, or Zn2+. Neither human alpha-f...

alpha-fetoprotein (afp), a serum glycoprotein belonging to the onco-developmental proteins group, serves as a marker both in cancer research and in studies concerning fetal development and fetal pathophysiology. monoclonal anti-afp antibodies are essential reagents in developing appropriate techniques for measurement of this protein. in this study, in order to produce anti-afp monoclonal antibo...

Expression of the mouse alpha-fetoprotein gene in embryonic, adult, and neoplastic tissues was assessed by RNA dot hybridization using 32P-labeled alpha-fetoprotein cDNA as probe, alpha-fetoprotein mRNA was present in high levels in total RNA from yolk sac endoderm, fetal liver, and an alpha-fetoprotein-producing hepatoma. In contrast, this mRNA was greatly depleted in total RNA from yolk sac m...

abstract background: preterm labor (delivery after 20 weeks and before 37 weeks of gestation) is the leading cause of prenatal mortality in developed countries. many women who have pre term labor have abnom1ally high plasma levels of a-fetoprotein in early pregnancy. methods: this study was designed to evaluate the ability of this biochemical test and a clinical risk factor scoring system to pr...