conclusions the present clinical study suggests that the transmission of an hbv genotype other than genotype d, namely hbv genotype g, is possible in turkey. epidemiological and clinical information on genotype g infection is currently limited, and this is most likely due to its low prevalence throughout the world. therefore, it may be important to determine the epidemiologic and molecular char...

Background: Angiotensin I converting enzyme (ACE) is a Zinc metalloproteinase, converts Ang-I to Ang- II, a pro-inflammatory agent which may contribute to pathophysiology of some diseases like type 2 diabetes. Objective: To investigate the relationship between ACE I/D polymorphism and type 2 diabetes in 261 Iranian casecontrol pairs. Methods: 170 patients (85 type 2 diabetics with nephropathy a...

Breast Cancer (BC) is considered as one of the most important causes of death worldwide. Previous studies showed that apolipoprotein B mRNA- editing catalytic polypeptide-like 3 (APOBEC3) gene deletion significantly increased the risk of BC risk in Chinese and European women. The present study aimed to assess the possible impact of APOBEC3 deletion and the risk of BC in a sample of Iranian popu...

abstract background: naturally occurred hepatitis b virus (hbv) with surface mutations in a variety of chronic hepatitis b (chb) patients who have received no vaccine or hbig bearing substitutions in surface protein, have been reported. objectives: current knowledge concerning the prevalence of these naturally occurring surface antigen mutations among iranian carriers is limited. patients and m...

conclusions the distribution of amino acid mutations as well as the ratio between missense and silent nucleotide mutations (dn/ds) showed that a narrowly focused immune pressure had already been on the surface protein (especially ctl epitopes) which led to the emergence of escape mutants in these patients who were in tolerance phase of chronicity. materials and methods the surface genes from 17...

background: hepatitis b virus (hbv) infection is the most common cause of end-stage liver disease in iran. more than 70% of cases are negative for the hepatitis b e antigen (hbeag) and have a long-term response to antiviral therapy, as well as a high relapse rate after discontinuing lamivudine or interferon. these features could be due, in part, to genetic variation of the hbv genome. materials...

AIM To study the Hepatitis B virus (HBV) genotypes and their effect on the progression and outcome in patients with chronic liver diseases from New Delhi, India. METHODS Sera from 100 HBV-related chronic liver disease (CLDB) cases were tested for HBV genotype using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) and Type-specific primers-based PCR (TSP-PCR) targe...

The influence of rs4646994 polymorphism the ACE gene on affinity oxygen for hemoglobin among young men with different levels physical activity has been studied. 245 aged 20-22 years were included in study. All divided into three groups depending their motor activity: low (LMA), average (AMA) and high (HMA). SatO 2 , pO pCO p50 HbO analyzed capillary blood all examined men. It was found out that...

background α-adrenergic receptor 2a (adra2a) and angiotensin-converting enzyme (ace) genes have been variably associated with obesity and its related phenotypes in different populations worldwide. objectives this cross-sectional study aims to investigate the association of adrenergic receptor α2a (adra2a) rs553668 and angiotensin-converting enzyme (ace) i/d single nucleotide polymorphisms (snps...