In recent years a novel scientific discipline called psychoneuroimmunology has emerged that examines complex interdependence of the mind, brain, endocrine and immune system in health disease. Homeostasis (a self-referral phenomenon) plays an important role keeping person healthy it fundamental host defense. Many studies show stress (acute or chronic) creates disorder especially regulation. this...

The aim of this study was to examine the anti-inflammatory effects of co-administration of growthhormone-releasing peptide-2 (GHRP-2) and growth hormone (GH) on tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6) and inducible nitric oxide synthase (iNOS) gene expression induced by LPS in the mousebrain. Thirty-five male NMRI mice (25±5 g) were injected through the mouse tail vein with saline,...

Abbreviations: BC: Before Christ; UV: Ultraviolet; NCBI: National Center For Biotechnology Information; Mirna: Microrna; IL-1: Interleukin 1; MSH: Melanocyte Stimulating Hormone; ACTH: Adrenocorticotropic Hormone; LH: Luteinizing Hormone; FSH: Follicle-Stimulating Hormone; MC1R: Melanocortin Type 1 Receptor; ER: Estrogen Receptor ; PR :Progesterone Receptor; TPO: Thyroid Peroxidase; TSH: Thyroi...

in this article, we present the case of a 12-year-old female child who complained of bilateral temporal and frontal headache for 2 to 3 months with nausea and vomiting. physical examination revealed right-sided sixth cranial nerve palsy and papilledema in ophthalmoscopy. to find the cause of increased intracranial pressure, the patient underwent brain imaging and brain mri showed no abnormality...

Exposure to bacterial endotoxins has long been known to stimulate the release of anterior pituitary hormones; administration of endotoxin was at one time a common clinical test of anterior pituitary function. Endotoxin is a potent stimulus for production of the endogenous pyrogenic protein, interleukin-1 (IL-1), by macrophages and monocytes. The possibility that IL-1 has a direct effect on the ...

This study evaluated the effects of a modern antagonistic analog of GHRH on tumor growth and on expression of inflammatory cytokine genes in two models of human triple negative breast cancers (TNBC). The TNBC subtype is refractory to the treatment options available for other hormone-independent breast cancers. Inflammatory cytokines play a major role in the cellular signaling associated with br...

The purpose of this study was to measure serum levels insulin-like growth factor-binding protein (IGFBP7), Insulin-like Growth Factor 1 (IGF-1), Hormone (GH), Interleukin 6 (IL-6) and insulin in acromegaly patients healthy controls. group had 60 patients, while the population 30 people who never before. concentration IGFBP7, IGF-1, GH, IL-6, were determined. results present indicate that IGFBP7...