In 2020, the World Health Organization declare a SARS-CoV-2 pandemic. There are currently more than 10 million people infected. Mao et al [1] demonstrated that 36.4% of hospitalized patients diagnosed with Covid-19 have presented neurological manifestations, where most severe likely to develop said percentage them having alteration as initial manifestation COVID-19. Among manifestations disease...

Objective—To delineate the possible implication of the immunosuppressive cytokine transforming growth factor beta 1 (TGF-â1) in the pathogenesis of GuillainBarré syndrome. Guillain-Barré syndrome is a disorder that may implicate cytokines in its pathogenesis. TGF-â1 is a potent anti-inflammatory cytokine occasionally shown to be regulated in the course of demyelinating disorders. Methods—The st...

We present a novel approach to find relevant features for identifying four subtypes of GuillainBarré Syndrome (GBS). Our method consists of a combination of Quenching Simulated Annealing (QSA) and Partitions Around Medoids (PAM), named QSA-PAM method. A 156-feature real dataset containing clinical, serological and nerve conduction test data from GBS patients was used for experiments. Different ...

20:446–452. 27. Papadea C, Check IJ. Human immunoglobulin G, immunoglobulin G subclasses: biochemical, genetic, and clinical aspects. Crit Rev Clin Lab Sci 1989;27:27–58. 28. Jacobs BC, Endtz HP, Van der Meché FGA, Hazenberg MP, De Klerk MA, Van Doorn PA. Humoral immune response against Campylobacter jejuni lipopolysaccharides in GuillainBarré and Miller Fisher syndrome. J Neuroimmunol 1997;79:...

Chronically ill patients with neurodegenerative and neurobehavioural and psychiatric diseases commonly have systemic and central nervous system bacterial and viral infections. In addition, other chronic illnesses where neurological manifestations are routinely found, such as fatiguing and autoimmune diseases, Lyme disease and Gulf War illnesses, also show systemic bacterial and viral infections...

A 48-year-old man presented with ascending sensory deficits over 12 hours, followed by urinary retention. He had areflexia, mild lower extremity weakness, sensory ataxia, and a T2 sensory level. Smooth pursuit was impaired, but cranial nerves were otherwise normal. Diagnostic evaluation demonstrated CSF cytoalbuminologic dissociation and demyelinating polyneuropathy fulfilling the electrodiagno...

A 44yearold woman was diagnosed with GuillainBarré syndrome (GBS) on day 5 after admission. She also suffered from chest pain early morning every day after admission. The severity of her GBS was Hughes functional grade four without any autonomic dysfunction. Cardiac enzymes (creatine kinaseMB and troponin I) were not elevated; however, T waves in leads II, III, aVF, and V2 through V5 on electro...

M elanoma is the most deadly skin cancer, with 75,000 new diagnoses annually, 15% of which are unresectable. Metastatic melanoma is a devastating diagnosis; before 2011, prognosis had remained relatively unchanged for 40 years and included a 5-year survival rate of 15%. However, in 2011, the Food and Drug Administration approved 2 drugs, ipilimumab and vemurafenib, which proved groundbreaking i...