OBJECTIVE Proton pump inhibitors (PPIs) are widely used, and their use is associated with increased risk of adverse events. However, whether PPI use is associated with excess risk of death is unknown. We aimed to examine the association between PPI use and risk of all-cause mortality. DESIGN Longitudinal observational cohort study. SETTING US Department of Veterans Affairs. PARTICIPANTS P...

Introduction: Gastric acidity plays an important role in the protection of infants against various pathogens from environment. The histamine-2 receptor blockers (H2-blockers) are off-labeled drugs that frequently prescribed preterm neonates to prevent stress ulcers. impact H2-blockers on development necrotizing enterocolitis (NEC) is still controversial, particularly developing world. Materials...

Histamine (H2) receptor antagonists, such as cimetidine and ranitidine, became available in the late 1970s and presently number among the most commonly used drugs. Cimetidine has been hypothesized to exert a cancer preventive effect on the prostate due to its ability to inhibit the binding of dihydrotestosterone to androgen receptors. Other hormonal effects of this drug include increases in ser...

Histamine (H2) receptor antagonists, such as cimetidine and ranitidine, became available in the late 1970s and presently number among the most commonly used drugs. Cimetidine has been hypothesized to exert a cancer preventive effect on the prostate due to its ability to inhibit the binding of dihydrotestosterone to androgen receptors. Other hormonal effects of this drug include increases in ser...

We studied the effect of histamine and H1 or H2 blockers on the diameter of pial arteries (39-227 micron) using microapplication into the perivascular space. Concentration-response curves for histamine showed dilations which started at 10(-7) M and were maximal at 10(-5) and 10(-4) M. The H2 blocker, cimetidine, induced no vascular reaction over the whole concentration range tested (10(-7) to 1...

BACKGROUND necrotizing enterocolitis is a serious condition that affects mostly preterm infants, with high mortality rate. AIM to estimate the influence of potentially contributing factors of this multifactorial disease. METHODS the study group included 51 necrotizing enterocolitis infants who were less than 37 week gestation who were hospitalized in NICU during a five year period. The cont...