Immigration is often seen as an instrument of adaptation for aging countries. In this paper, we evaluate, using a dynamic general equilibrium model, the contribution of migration policy in reducing the tax burden associated with the aging population in France. Four alternative scenarios, compared to a baseline scenario based on official projections, are simulated with the aim to quantify the im...

In 2011, the publicly held debt-to-GDP ratio in the United States reached 68% and is expected to continue rising. Many proposals to curb the government de…cit and the resulting debt are being discussed. In this paper, we use the standard neoclassical growth model to examine the future path of output, budget de…cits, and debt in the U.S. economy under di¤erent tax policies. While this framework ...

Viral myocarditis (VMC) most prevalently caused by coxsackievirus B3 (CVB3) infection is characterized by severe cardiac inflammation. Therapeutic options for the disease are still limited. Astragaloside IV (AST-IV), a purified small molecular saponin (C41 H68 O14 , MW 784), is the main active component of Chinese medical herb Astragalus which has been empirically prescribed for the treatment o...

Rhodostomin (Rho) is a medium disintegrin containing a 48PRGDMP motif. We here showed that Rho proteins with P48A, M52W, and P53N mutations can selectively inhibit integrin αIIbβ3. To study the roles of the RGD loop and C-terminal region in disintegrins, we expressed Rho 48PRGDMP and 48ARGDWN mutants in Pichia pastoris containing 65P, 65PR, 65PRYH, 65PRNGLYG, and 65PRNPWNG C-terminal sequences....

14-3-3σ overexpression results in enhanced hepatocellular carcinoma (HCC) cell migration and HCC tumor vascular-invasion is significantly associated with 14-3-3σ expression. However, increased expression of 14-3-3σ paradoxically suppresses in vitro cell invasion of HCC. We hypothesize that surrounding tumor-associated stromal cells play a crucial role in 14-3-3σ-regulated HCC cell invasion. In ...

a r t i c l e i n f o JEL classification: Q43 Q54 C68 D58 H50 H68 Keywords: Fuel prices Endogenous growth Budgetary consolidation Climate policy Dynamic general equilibrium Portugal This paper examines the influence of fossil fuel prices on carbon dioxide emissions, economic activity, and the public sector account in Portugal. It uses a dynamic general equilibrium model which highlights the mec...

•Cryo-EM structure of human BARD1 in complex with H2AK15-ubiquitinated nucleosome•The BUDR motif contacts the nucleosome acidic patch and ubiquitin K63-E64•The ARD domain grips H4 tail by accommodating unmethylated H4K20•Mutations disrupting BARD1-NCPUb association impair homologous recombination The BRCA1-BARD1 directs DNA double-strand break (DSB) repair pathway choice to error-free (HR) duri...