The branching angle and diameter ratio in epicardial coronary artery bifurcations are two important determinants of atherogenesis. Murray's cubed diameter law and bifurcation angle have been assumed to yield optimal flows through a bifurcation. In contrast, we have recently shown a 7/3 diameter law (HK diameter model), based on minimum energy hypothesis in an entire tree structure. Here, we der...

Introduction: Although hippocampus is the most famous brain area involved in temporal lobe epilepsy, hippocampal kindling (HK) develops very slowly. Hence, rapid kindling is usually preferred to the traditional kindling and it is widely used. In this article we aimed at finding the optimal stimulus pattern, which yields the fastest HK rate. Methods: Stimulus patterns with different duratio...

This paper presents a new methodology for friction compensation that is not based on any friction model. This is done by using finite-terms Fourier series to approximate the friction term. Updating laws for the coefficients of the series are easily derived from a Lyapunov approach to guarantee asymptotic convergence of the tracking error. Computer simulations are then proposed in which friction...

The function hK is called the support function of K because it provides information on support hyperplanes and halfspaces of K . Indeed, every support halfspace of K is of the form {x :x · u≤ hK(u)} for some u ∈ Sd−1 and since K equals the intersection of all its support halfspaces, the function hK uniquely determines K . For a proof of this and other elementary properties of the support functi...

the forging model for cold rolling is one of rolling models that is used in rolling calculations. in this model,the final rolling pressure is an average value and it is not an accurate model.also by using this model,the firction hill curves are plotted due to the central point of the rolling bite length while frictional stresses intersect at the neutral point.in this study, a new model based on...

In opinion dynamics, how to model the enduring fragmentation phenomenon (disagreement, cleavage, and polarization) of social opinions has long possessed a central position. It is widely known that the confidence-based opinion dynamics provide an acceptant mechanism to produce fragmentation phenomenon. In this study, taking the famous confidence-based Hegselmann-Krause (HK) model, we examine the...

Glucose (Glc) metabolism protects cells against oxidant injury. By virtue of their central position in both Glc uptake and utilization, hexokinases (HKs) are ideally suited to contribute to these effects. Compatible with this hypothesis, endogenous HK activity correlates inversely with injury susceptibility in individual renal cell types. We recently reported that ectopic HK expression mimics t...

BACKGROUND Hexokinase-2(HK-2) plays dual roles in glucose metabolism and mediation of cell apoptosis, making it an attractive target for cancer therapy. Chrysin is a natural flavone found in plant extracts which are widely used as herb medicine in China. In the present study, we investigated the antitumor activity of chrysin against hepatocellular carcinoma (HCC) and the role of HK-2 played for...

Most organisms anticipate daily environmental variations and orchestrate cellular functions thanks to a circadian clock which entrains robustly to the day/night cycle, despite fluctuations in light intensity due to weather or seasonal variations. Marine organisms are also subjected to fluctuations in light spectral composition as their depth varies, due to differential absorption of different w...