conclusions pretreatment with epo and application of ipc significantly ameliorated the renal injury induced by bilateral renal ir. however, both treatments attenuated renal dysfunction and oxidative stress in kidney tissues. there were no significant differences between pretreatment with epo or application of ipc. materials and methods twenty four male wistar rats were allocated into four exper...

background: it has been reported that the chronic oral administration of garlic homogenate protected the rat heart from in vitro ischemic reperfusion injury. however, the biological effects of garlic juice on the heart are expected to be different from oral administration of it. objective: the present study was designed to investigate the effect of garlic juice on the isolated rat heart in isch...

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main source(s): Research, Development and Innovation Office Hungary (NKFIA; NVKP-16-1-2016-0017 Heart Program OTKA-FK 134751) MTA-SE System Pharmacology Research Group, Department Pharmacotherapy, Semmelweis University, H-1089 Budapest, Ischemic heart disease is the leading cause death worldwide; ...

BACKGROUND Ventricular arrhythmias occur more frequently in heart failure during episodes of ischemia-reperfusion although the mechanisms underlying this in humans are unclear. We assessed, in explanted human hearts, the remodeled electrophysiological response to acute ischemia-reperfusion in heart failure and its potential causes, including the remodeling of metabolic gene expression. METHOD...

Background:Troxerutin has antioxidant and anti-inflammatory properties and in this study, its antioxidant effect on the reduction of oxidative stress induced by ischemia-reperfusion sciatic nerve injury was investigated. Methods:In this study, 64 male rats were randomly divided into 8 groups as follows: 1- IR2: ischemia (3 hours) and reperfusion (2 days), 2- T...

Cerebral ischemia-reperfusion (CIR) injury is initiated by the generation of reactive oxygen species (ROS), which leads to oxidation cellular proteins, DNA, and lipids as an initial event. The reperfusion process impairs critical cascades that support cell survival, including mitochondrial biogenesis antioxidant enzyme activity. Failure activate prosurvival signals may result in increased neuro...

Background: Cerebral ischemic reperfusion injury (CI/RI) is a common cerebrovascular disease with high morbidity and disability that threatens human health. This study was conducted to explore the effects of dexmedetomidine (Dex) on c-Jun N-terminal kinase (JNK) pathway in CI/RI, provide theoretical basis for recovery brain function after cerebral ischemia.

Organ damage after reperfusion of previously viable ischemic tissues is defined as ischemia/reperfusion injury. The pathophysiology of ischemia/reperfusion injury involves cellular effect of ischemia, reactive oxygen species and inflammatory cascade. Protection against ischemia/reperfusion injury may be achieved by preconditioning or postconditioning. In this review, we discuss basic mechan...