Aim Insulin-like growth factor 1 (IGF-1), which is primarily produced in hepatocytes and associated with liver functional reserve, plays a crucial role the pathological condition of cirrhosis. This study aimed to investigate usefulness serum IGF-1 levels for predicting long-term prognosis decompensation development patients Methods We retrospectively evaluated 148 cirrhosis divided them into th...

Obesity is an important factor that threatens human health. The occurrence of many chronic diseases related to obesity, and cognitive function decline often occurs with the onset obesity. With further prevalence it bound lead a wider range dysfunction (ORCD). Therefore, crucial suppress ORCD through intervention. In this regard, exercise has been shown be effective in preventing obesity improvi...

To investigate the effects and potential mechanisms of chicoric acid (CA) on LPS-induced inflammatory response in A549 cells. 0–800 μM CA was added to cells determine toxicity using MTT assay. Then, 2 μg/mL LPS 50 were simultaneously CA. In order miR-130a-3p IGF-1 cells, infected with inhibitor si RNA IGF-1. The levels cytokines such as IL-1β, IL-6, TNF-α measured by real-time RT-PCR enzyme-lin...

results 100 patients with cirrhosis with a male to female ratio of 63:37 and a mean age of 44.4 ± 15 years were enrolled in the study. median igf-1 was 92.95 ± 91.51 ng/ml. 14 patients (14%) had igf-1 within normal limits while 86 patients (86%) had abnormal igf-1 levels. in all patients the correlation coefficient between igf-1 and meld was -0.317 (p = 0.001) and 0.478 between igf-1 and child-...

There is increasing evidence to indicate that insulin‑like growth factor (IGF)‑1 plays a crucial role in the regeneration of different tissues following injury. Notably, despite escalating number animal studies, studies investigating IGF‑1 wound healing process humans are fewer. In this context, aim present study was evaluate variations expression isoforms (IGF1‑Ea, IGF1‑Eb and IGF1‑Ec), as wel...

abstract introduction: there is limited knowledge available on the metabolism of glucose in the brain, an insulin insensitive organ. insulin receptors hybridize with insulin like growth factor receptor (igf-i) to transduce the signals in different areas of the brain. in this article we aimed at investigating whether the expression of igf-i receptor and igf-i binding proteins (igfbp1) is changed...