Currently, liver transplantation is the most effective treatment for end-stage disease. Immuno-suppressive agents are required to be taken after operations, which have significantly reduced rejection rates and improved short-term (<1 year) survival rates. However, post-transplant complications related immuno-suppressive therapy led development of new protocols aimed at protecting renal funct...

Purpose Severing corneal nerves during corneal transplantation does not affect first corneal transplants, but abolishes immune privilege of subsequent corneal allografts. This abrogation of immune privilege is attributable to the disabling of T regulatory cells (T regs) induced by corneal transplantation. The goal of this study was to determine if severing corneal nerves induces the development...

Pregnancy is a physiological condition that requires immune tolerance to the product of conception. Systemic lupus erythematosus (SLE) is a disease with well-represented immune mechanisms that disturb immune tolerance. The association of pregnancy with systemic lupus erythematosus creates a particular immune environment in which the immune tolerance specific of pregnancy is required to coexist ...