The in vitro susceptibility of an infecting organism to the antimicrobial agent selected for therapy is one of several factors that influence the likelihood that therapy for an infection will be successful. To appreciate the value of antifungal susceptibility testing, it is helpful to review the overall predictive utility of antibacterial susceptibility testing. After >30 years of study, in vit...

background: this study was designed to detect whether there is a correlation between in vitro susceptibility of field isolates of leishmania major and the clinical outcomes of meglumine antimoniate (glucantime®) therapy, the main­stay of cutaneous leishmaniasis treatment in iran. methods: forty-three patients infected with l. major were enrolled in this study from october 2009 to march 2010 and...

aspergillus terreus is emerging as an etiologic agent of invasive aspergillosis among patients undergoing cancer chemotherapy, haematopoetic stem-cell transplantation, or solid organ transplantation worldwide. infections caused by aspergillus terreus has become important due to less susceptibility to antifungal drags, resistant to amphotericin b and therefore, poor clinical outcome and higher m...

silver nanoparticles (agnps) are known to have bactericidal and fungicidal effects. since, there is few information available on the interaction of colloidal nanosilver with fish pathogens. hence, the current study investigated the effects of colloidal agnps on the in vitro growth of the fish pathogen saprolegnia sp.. before the experiments, various important properties of agnps were well-chara...

We have determined the in vitro susceptibilities of 57 strains of Cryptococcus gattii to nine antifungal agents and have compared the MICs for these strains with those for C. neoformans. MICs were determined by a microdilution reference method. Albaconazole and ravuconazole (MICs of 0.04 and 0.05 microg/ml, respectively) showed the best activities. Micafungin showed no activity (MIC of >128 mic...

Background and Purpose: Candida albicans is the most common causative agent of candidiasis. Candidiasis management is dependent on the immune status of the host, severity of disease, and the choice of antifungal drug. Antifungals, specifically triazoles, are widely administered for the treatment of invasive fungal infections. Herein, we aimed to evaluate the in vitro susceptibility of C. alb...

Reliable measures of antifungal drug susceptibility are needed. We tested the susceptibility of Cryptococcus neoformans from patients treated with amphotericin B. In vitro susceptibility employed a modified broth macrodilution method. We demonstrate a strong correlation between the quantitative measures of in vitro amphotericin B susceptibility and the quantitative response observed in patients.

background: although  candida albicans  remains the most common fungal isolate from clinical specimens, many studies have detected a shift towards non-albicans  candida species. despite worrying clinical pictures associated with latter species , there is little information regarding its susceptibility patterns against currently available antifungal agents, with only a small number of strains ha...

New molecular identification techniques and the increased number of patients with various immune defects or underlying conditions lead to the emergence and/or the description of novel species of human and animal fungal opportunistic pathogens. Antifungal susceptibility provides important information for ecological, epidemiological and therapeutic issues. The aim of this study was to assess the ...