OBJECTIVES To compare the effectiveness of an early switch to oral antibiotics with the standard 7 day course of intravenous antibiotics in severe community acquired pneumonia. DESIGN Multicentre randomised controlled trial. SETTING Five teaching hospitals and 2 university medical centres in the Netherlands. PARTICIPANTS 302 patients in non-intensive care wards with severe community acqui...

Pulmonary exacerbations in adults with cystic fibrosis (CF) and chronic Pseudomonas aeruginosa (Psae) infection are usually treated with dual intravenous antibiotics for 14 days, despite the lack of evidence for best practice. Intravenous antibiotics are commonly associated with various systemic adverse effects, including renal failure and ototoxicity. Inhaled antibiotics are less likely to cau...

A retrospective study of patients with cerebrospinal fluid shunt infections was undertaken from 1975 to 1989 in a university hospital. The data were analyzed with emphasis on the choice of treatment and outcome. There were 44 infectious episodes in 38 patients for an overall rate of 2.6%, including 30 ventriculoperitoneal, 11 ventriculoatrial and 3 lumboperitoneal shunts. The most frequently is...

The purpose of this study is to determine whether, in low-risk febrile neutropenic paediatric populations, oral antibiotics are as effective as intravenous antibiotics in obtaining resolution of the febrile neutropenic episode. A comprehensive literature search of MEDLINE, EMBASE and CENTRAL identified prospective, randomised controlled trials comparing oral antibiotics with intravenous antibio...

Cellulitis is treated with antibiotics as routine management and based on the literature cellulitis hospitalization can be avoided by 11% if appropriate are used.1 Randomized clinical trials Cochrane reviews have suggested that oral non-inferior to intravenous administration (1). We would like highlight here unrequired use of in cellulitis. Intravenous recommended patients sepsis. This supporte...

Hospitalized patients initially on intravenous antibiotics can be safely switched to an oral equivalent within the third day of admission once clinical stability is established. This conversion has many advantages as fewer complications, less healthcare costs and earlier hospital discharge. The three types of intravenous to oral conversion include sequential, switch, and step-down therapy. The ...

Introduction: The standard treatment protocol of orbital cellulitis includes the use broad-spectrum intravenous antibiotics. This study was done to evaluate role oral corticosteroids in order address inflammatory component. Methods: A prospective comparative interventional carried out on 17 cases over 16 months. All patients were treated with antibiotics and allotted Group or B. former consiste...