IN the course of experiments on the toxicity of iodoacetic acid to biological processes, it was found that addition to the acid of sodium thiosulphate or thiol compounds brought about a considerable diminution in the intensity of the toxic effect. This observation led the writers to consider the possibility that thiol compounds may normally play an important part in the processes affected by io...

GOODALE, ROBERT L., BOYD GOETZMAN, AND MAURICE B. VISSCHER. Hypoxia and ioduacetic acid and alveohzpillary barrier permeability to albumin, Am. J. Physiol. 219(5): 12264230. 1970Perfusion studies at controlled flow rates using the isolated left lower lobe of the canine lung were performed under normal oxygen tensions and under conditions of low 0, tension, averaging 12 mm Hg. The average permea...

Neighboring iodo-, alkoxy-, acetoxyand silyl groups impart useful levels of diastereoselection in the Lewis acid-mediated allylation of monoperoxyacetals. Although monoperoxyacetals are found to be considerably less reactive than corresponding nonperoxidic acetals, similar stereochemical trends are observed in the two series.

We have found a novel prolyl aminopeptidase in Grifola frondosa. The enzyme was purified by DEAE-Sepharose CL-6B, Butyl-Toyopearl, Sephacryl S-100, and Mono-Q column chromatographies. The purified enzyme exists as a dimer and gives high activity toward L-proline-p-nitroanilide. The enzyme was strongly inhibited by p-chloromercuribenzoic acid and iodoacetic acid and markedly inhibited by phenylm...

The manganese-enzyme-substrate complexes of a number of nucleoside diphosphate substrates of creatine kinase showed a range of enhanced values of the longitudinal proton relaxation rate of water with respect to the manganous aquocation, although the small enhancement factors, ca, of all the binary manganese-nucleotide complexes were the same, approximately 1.6. The order of the values of t, the...

Stem bromelain that had been irreversibly inhibited with 1,3-dibromo[2-(14)C]-acetone was reduced with sodium borohydride and carboxymethylated with iodoacetic acid. After digestion with trypsin and alpha-chymotrypsin three radioactive peptides were isolated chromatographically. The amino acid sequences around the cross-linked cysteine and histidine residues were determined and showed a high de...