Shigella flexneri invades colonic epithelial cells by pathogen-induced phagocytosis. The three proposed effectors of S. flexneri internalization are invasion plasmid antigens B (IpaB), IpaC, and IpaD, which are encoded on the pathogen's 230-kb virulence plasmid and translocated to the extracellular milieu via the Mxi-Spa translocon. To date, there are no definitive functional data for any purif...

We have investigated the capacity of live attenuated Shigella flexneri strains to act as vectors for the induction of local and systemic antibody responses against heterologous epitopes. The S. flexneri IpaC antigen was selected as a carrier protein into which the C3 neutralizing epitope of the poliovirus VP1 protein was inserted in eight sites distributed along IpaC. The resulting IpaC-C3 hybr...

I review the current knowledge of high-energy emission from extragalctic jets. First I discuss γ-ray emission from blazars, which provides us numerous precious information on the innermost portions of the relativistic jets. I describe the constraints on the dynamics of the jet from the subpc to the pc scale provided by recent VLBI studies of TeV sources, together with the modelling of the emiss...

The products of the ipaB, ipaC, and ipaD genes are involved in the expression of the invasive phenotype in all species of Shigella and enteroinvasive Escherichia coli (EIEC). DNA probes derived from these genes are accurate indicators of the invasive phenotype (M. Venkatesan, J. M. Buysse, E. V. Vandendries, and D. J. Kopecko, J. Clin. Microbiol. 26:261-266, 1988); however, spontaneous loss of ...

Shigella flexneri causes human dysentery after invading the cells of the colonic epithelium. The best-studied effectors of Shigella entry into colonocytes are the invasion plasmid antigens IpaC and IpaB. These proteins are exported via a type III secretion system (TTSS) to form a pore in the host membrane that may allow the translocation of other effectors into the host cytoplasm. TTSS-mediated...

Canadian Public AdministrationVolume 66, Issue 1 p. 149-149 ISSUE INFORMATION - IPACFree Access Information IPAC First published: 21 March 2023 https://doi.org/10.1111/capa.12476AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review our Terms and Conditions of Use check box below share version article.I h...

Shigella flexneri contact with enterocytes induces a burst of protein secretion via its type III secretion apparatus (TTSA) as an initial step in cellular invasion. We have previously reported that IpaD is positioned at the TTSA needle tip (M. Espina et al., Infect. Immuno. 74:4391-4400, 2006). From this position, IpaD senses small molecules in the environment to control the presentation of Ipa...

P.N. Appleton (IPAC), A.W. Blain (Caltech), C.M. Bradford (JPL), C.R. Bridge (SSC), R. Chary (SSC), E. Daddi (CEA Saclay), V. Desai (SSC), M. Harwit (Cornell), G. Helou (IPAC), P.F. Hopkins (UC Berkeley), M. Malkan (UCLA), J. Melbourne (Caltech), E.J. Murphy (SSC), P. Ogle (SSC), C. Papovich (Texas A&M), A. Pope (NOAO), D. Riechers (Caltech), J.R. Rigby (OCIW), J.D. Smith (Toledo), G. Stacey (C...