OBJECTIVES To describe the incidence and risk factors for the development of indinavir-associated renal complications (IRC), and subsequent clinical outcome. PATIENTS AND METHODS This was a retrospective cohort study based on two large HIV centres in London. Eligible patients received indinavir for at least 1 week between 1 December 1995 and 28 February 1999. Development of IRC was ascertaine...

PURPOSE To develop a software algorithm to perform automated segmentation of retinal layer structures on linear macular optical coherence tomography (StratusOCT; Carl Zeiss Meditec, Inc., Dublin, CA) scan images and to test its performance in discriminating normal from glaucomatous eyes in comparison with conventional circumpapillary nerve fiber layer (cpNFL) thickness measurement. METHODS Fo...

In this paper, we apply social network analytic methods to unveil the structural dynamics of a popular open source goal oriented IRC community, Ubuntu. The primary objective is to track the development of this ever growing community over time using a social network lens and examine the dynamically changing participation patterns of people. Specifically, our research seeks out to investigate ans...

Iterated Register Coalescing (IRC) is a widely used heuristic for performing register allocation via graph coloring. Many implementations in existing compilers follow (more or less faithfully) the imperative algorithm published in 1996. Several mistakes have been found in some of these implementations. In this paper, we present a formal verification (in Coq) of the whole IRC algorithm. We detai...

Purpose To identify the spatial distribution of exudative features of choroidal neovascularization in neovascular age-related macular degeneration (nAMD) based on the localization of intraretinal cystoid fluid (IRC), subretinal fluid (SRF), and pigment-epithelial detachment (PED). Methods This retrospective cross-sectional study included spectral-domain optical coherence tomography volume sca...

Policy challenges are increasingly transcending national borders. Examples range from dealing with a global health crisis, climate change and biodiversity to consumer safety or protection of personal data. These cannot be addressed by countries unilaterally. This is why international regulatory co-operation (IRC) has become central policymaking policy, as it enables governments collaborate on c...

We obtained BV IC photometry of IRC−10443 in 85 different nights distributed over two years, and in addition low resolution absolute spectrophotometry and high resolution Echelle spectroscopy. Our data show that IRC −10443, which was never studied before in any detail, is a SRa variable, characterized by ∆B=1.27, ∆V=1.14 and ∆I=0.70 mag amplitudes and mean values =13.75, =11.33 and =...

Within the framework of an exploratory Human Factors study three systems were examined in terms of their usefulness and usability for informal communication of distributed work groups: An Internet Relay Chat (IRC) system, an IRC system supplemented by Webcam pictures (i.e. periodically updated still pictures on a Web page), and a virtual environment system. Results showed, among other things, t...

Insulin recruits two transmembrane proteins, GLUT4 and IRAP, to the plasma membrane of muscle cells and adipocytes. The subcellular trafficking and localization of GLUT4, and to a lesser extent IRAP, have been intensely studied, yet the molecular mechanisms responsible for their insulin-responsive compartmentalization remain unknown. Herein we have investigated the endocytosis and recycling of ...

To date, techniques to counter cyber-attacks have predominantly been reactive; they focus on monitoring network traffic, detecting anomalies and cyber-attack traffic patterns, and, a posteriori, combating the cyber-attacks and mitigating their effects. Contrary to such approaches, we advocate proactively detecting and identifying botnets prior to their being used as part of a cyber-attack [12]....