The vasomotor response to cold may compromise the capacity for microclimate cooling (MCC) to reduce thermoregulatory strain. This study examined the hypothesis that intermittent, regional MCC (IRC) would abate this response and improve heat loss when compared with constant MCC (CC) during exercise heat stress. In addition, the relative effectiveness of four different IRC regimens was compared. ...

PURPOSE To investigate the use of liposomal irinotecan (Irinophore C™) plus or minus 5-fluorouracil (5-FU) for the treatment of colorectal cancer. EXPERIMENTAL DESIGN The effect of irinotecan (IRI) and/or 5-FU exposure times on cytotoxicity was assessed in vitro against HT-29 or LS174T human colon carcinoma cells. The pharmacokinetics and biodistribution of Irinophore C™ (IrC™) and 5-FU, admi...

introduction: vesico-urethral reflux (vur) is the most common complication of urinary-tract infection (uti). detecting vur has been classically achieved by voiding cystourethrography (vcug). radionuclide cystography will detect vur, but fails to provide the same detailed anatomical information as vcug. this study designed to compare the irc and vcug. materials & methods: this study has been don...

BACKGROUND Our objective was to determine the variability in assessment between investigators (INV) and independent review committees (IRC) for response rate (RR) and progression-free survival (PFS). METHODS Phase III trials reporting INV and IRC assessments were identified. The difference in end point assessment (IRC - INV) across all study arms was determined. A random-effects model was use...

We present an anomaly-based algorithm for detecting IRC-based botnet meshes. The algorithm combines an IRC mesh detection component with a TCP scan detection heuristic called the TCP work weight. The IRC component produces two tuples, one for determining the IRC mesh based on IP channel names, and a sub-tuple which collects statistics (including the TCP work weight) on individual IRC hosts in c...

The intrinsic reaction coordinate (IRC) approach has been used extensively in quantum chemical analysis and prediction of the mechanism of chemical reactions. The IRC gives a unique connection from a given transition structure to local minima of the reactant and product sides. This allows for easy understanding of complicated multistep mechanisms as a set of simple elementary reaction steps. In...

The 11 km fringe visibilities of IRC ]10011 (\ CIT3) and IRC ]10420 have been measured at baselines ranging from 2 to 14 m with a two-telescope interferometer. The visibility data provide onedimensional proÐles of these two stars and their immediate surroundings with higher resolution in this spectral range than is presently possible with a single-aperture telescope. Spherically symmetric radia...

Botnets are considered one of the most dangerous and serious security threats facing the networks and the Internet. Comparing with the other security threats, botnet members have the ability to be directed and controlled via C&C messages from the botmaster over common protocols such as IRC and HTTP, or even over covert and unknown applications. As for IRC botnets, general security instances lik...

Developers of open source projects are distributed across the world. They rely on email, mailing lists, instant messaging and more recently IRC channels to communicate. Most of the studies thus far focus on the use of mailing lists by OSS developers, however, an increasing number of open source projects are using IRC channels to hold developer meetings. In many cases, these IRC meetings supplem...

indoor radon concentration (irc) is among the emerging environmental and health issues in republic of korea. due to lack of epidemiological studies and insufficient public awareness about radon, effective parameter ranking system is required to establish protocols for future field sampling and settlement construction. this research propose the irc parameter ranking system based on field measure...