INTRODUCTION AND OBJECTIVES Immune response-mediated regulation of myocardial collagen remains poorly understood. Our objective was to investigate the relationship between ventricular remodeling and immunologic activation in patients with heart failure (HF) by comparing dilated and ischemic cardiomyopathy. METHODS We studied 94 patients with HF and dilated cardiomyopathy (n=46) or ischemic ca...

Recent trends indicate that patients with nonischemic dilated cardiomyopathy represent the largest subpopulation of heart failure patients with a significant need for alternative treatment modalities. Similar to patients with ischemic cardiomyopathy, patients with nonischemic dilated cardiomyopathy have been found to have myocardial regions with flow abnormalities, which may represent targets f...

Stem cell therapy for heart failure is a rapidly progressing field. The objective of this study was to assess the safety, and short-term results of thoracoscopic direct injection of angiogenic cell precursors into patients with endstage cardiomyopathy. Cells were obtained from the patient's own blood, avoiding immunological concerns. The number of cells prior to injection was 29.1 +/- 18.9 x10(...

Cardiac involvement is a rare complication with thromboangiitis obliterans (TAO). We report a 29-year-old man with TAO accompanied with non-ischemic dilated cardiomyopathy. He had no history of heart disease, but echocardiogram demonstrated diffuse hypokinesis and dilated left ventricle. Coronary angiography revealed no organic stenotic lesion. For limb salvage, he was treated with granulocyte-...

The idiopathic dilated cardiomyopathy (IDMC) is a disease of the cardiac muscle characterized by systolic dilation and/or dysfunction of one or both ventricles, symptoms of congestive heart failure and risk of early death. Several studies in animal models and in humans have supported the hypothesis of the viral infection as initial event in the immunopathogenesis of the ventricular dilation. Th...

  Transient ischemic left ventricular dilation (TID) is a marker of severe and extensive coronary artery disease as well as an increased risk of adverse outcomes. The patients with more severe and extensive ischemia, multivessel-type of perfusion abnormality as well as patients with left anterior descending artery (LAD) territory perfusion abnormality have more probab...

discussion there are other causes of dilated cardiomyopathies which could be transient like peripartum cardiomyopathy. the development of biventricular mural thrombi is rare, and it mainly increases the risk of embolization in the systemic and pulmonary circulations. case presentation we present two case reports of post-myocardial infarction sequel leading to ischemic cardiomyopathy and peripar...

Objective: Patients with end stage ischemic dilated cardiomyopathy (IsDCM) exhibit extensive remodeling of the left ventricle, and significant mitral tricuspid regurgitation. We investigated if implantation artificial valve preservation native could be used as a method combined annuloplasty complete myocardial revascularization in IsDCM.

background: dilated cardiomyopathy (dcmp) is a myocardial disease characterized by dilated left ventricle or both ventricles and reduced contractility of the myocardium. in patients suffering from dcmp, the serum level of uric acid may increase. this research was designed to evaluate the effect of the serum level of uric acid on systolic and diastolic functions in patients with dcmp. methods: t...

BACKGROUND The present investigation was designed to obtain an absolute measurement of myocardial blood flow and of its transmural distribution in ischemic heart disease and idiopathic dilated cardiomyopathy and to provide a reference standard for cardiac imaging in nuclear cardiology. METHODS AND RESULTS Regional myocardial blood flow and its transmural distribution were estimated by the ref...