BACKGROUND In situ magnetic separation (ISMS) has emerged as a powerful tool to overcome process constraints such as product degradation or inhibition of target production. In the present work, an integrated ISMS process was established for the production of his-tagged single chain fragment variable (scFv) D1.3 antibodies ("D1.3") produced by E. coli in complex media. This study investigates th...

Security metrics are used to measure the effectiveness of an organisation's Information Security Management System (ISMS) as well as the sub-processes, activities and controls of the ISMS. Guidelines and example metrics have been published, but it is still difficult for an organisation to select metrics that are feasible for their environment, i.e. their ISMS. This paper proposes a self-assessm...

Purpose – The purpose of this study is proposing a model to determine the gaps between security standards requirements and the reality of implementation ISMS. Design/methodology/approach – The research approach analyzes the various industry standards relevant to information security and responses gained from interviewing with 45 individuals of IT professionals and information security experts (...

Ion-selective microelectrodes (ISMs) have been used extensively in neurophysiological studies. ISMs selective for H(+) and Ca(2+) are notable for their sensitivity and selectivity, but suffer from a slow response time, and susceptibility to noise because of the high electrical resistance of the respective ion exchange cocktails. These drawbacks can be overcome by using a "coaxial" or "concentri...